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NOX5 - NADPH oxidase 5 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79400

About NOX5

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:68,930,525-69,062,762 (from NCBI)

This gene has 6 transcripts (splice variants), 150 orthologues and 6 paralogues. Biased expression in spleen (RPKM 7.9), testis (RPKM 4.2) and 3 other tissues.

Summary

This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH Oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

NOX5 Products (3)

mRNA	Protein	Name
NM_001184779.2	NP_001171708.1	NADPH oxidase 5 isoform 2
NM_001184780.2	NP_001171709.1	NADPH oxidase 5 isoform 3
NM_024505.4	NP_078781.3	NADPH oxidase 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17346712	GOA
enables proton channel activity	IDA IDA: Inferred from direct assay	11483596	GOA
NOT contributes to superoxide-generating NAD(P)H oxidase activity	IDA IDA: Inferred from direct assay	22427510	GOA
enables superoxide-generating NAD(P)H oxidase activity	IDA IDA: Inferred from direct assay	11483596	GOA
enables superoxide-generating NAD(P)H oxidase activity	IMP IMP: Inferred from mutant phenotype	14982937	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in angiogenesis	IDA IDA: Inferred from direct assay	17275676	GOA
involved in endothelial cell proliferation	IDA IDA: Inferred from direct assay	17275676	GOA
involved in positive regulation of reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	17275676	GOA
involved in proton transmembrane transport	IDA IDA: Inferred from direct assay	11483596	GOA
involved in superoxide anion generation	IDA IDA: Inferred from direct assay	11483596	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	17275676	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17587483	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOX5 Protein Structure

EF-hand_6

EF-hand_5

Ferric_reduct

FAD_binding_8

NAD_binding_6

0
200
400
600
765 a.a.

Protein Preferred Names	Protein Names
NADPH oxidase 5	NADPH oxidase, EF-hand calcium binding domain 5

Related Diseases

Diseases	Alias
Colorectal Adenocarcinoma	Adenocarcinoma Of Large Intestine
Barrett'S Adenocarcinoma	Barrett Adenocarcinoma Adenocarcinoma Arising In Barrett'S Mucosa
Chronic Granulomatous Disease	Cgd Granulomatous Disease, Chronic Autosomal Recessive Chronic Granulomatous Disease X-Linked Chronic Granulomatous Disease Bridges-Good Syndrome Congenital Dysphagocytosis Quie Syndrome Chronic Septic Granulomatosis Chronic Granulomatous Disorder Granulomatous Disease Chronic Granulomatous Disease, Chronic, X-Linked
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0807A	Prochlorperazine dimaleate	Inhibitor	≥98.0%	Unkown

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148936	GLX481372	Inhibitor	/	Unkown
HY-174817	NOX5-IN-1	Inhibitor	/	Unkown
HY-174818	NOX5-IN-2	Inhibitor	/	Unkown