Recql4 - RecQ protein-like 4 Gene

Also Known as RecQ4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 79456

Summary

Predicted to enable DNA binding activity and DNA helicase activity. Acts upstream of or within several processes, including negative regulation of sister chromatid cohesion; positive regulation of cell population proliferation; and skeletal system morphogenesis. Predicted to be located in chromosome, telomeric region. Predicted to be active in chromosome; cytoplasm; and nucleus. Is expressed in several structures, including Harderian gland; alimentary system; immune system; male reproductive gland or organ; and nervous system. Used to study Rothmund-Thomson syndrome. Human ortholog(s) of this gene implicated in Baller-Gerold syndrome; Rothmund-Thomson syndrome; and rapadilino syndrome. Orthologous to human RECQL4 (RecQ like helicase 4). [provided by Alliance of Genome Resources, Apr 2022]

Recql4 Products (2)

mRNA Protein Name
NM_001411974.1 NP_001398903.1 ATP-dependent DNA helicase Q4 isoform 2
NM_058214.4 NP_478121.2 ATP-dependent DNA helicase Q4 isoform 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of sister chromatid cohesion IMP
IMP: Inferred from mutant phenotype
15703196 MGI
acts upstream of or within pigmentation IMP
IMP: Inferred from mutant phenotype
15703196 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16600186 MGI
acts upstream of sister chromatid cohesion IMP
IMP: Inferred from mutant phenotype
15703196 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
16600186 MGI
acts upstream of or within skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
15703196 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-dependent DNA helicase Q4

  • DNA helicase, RecQ-like type 4

  • RecQ helicase protein-like 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11811 RECQL4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20589 Recql4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27097 Recql4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Recql4 NCBI NCBI:9401