FLAD1 - flavin adenine dinucleotide synthetase 1 Gene

Also Known as FAD1; FADS; PP591; LSMFLAD

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80308

About FLAD1

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:154,983,344-154,993,111 (from NCBI)

This gene has 12 transcripts (splice variants), 214 orthologues and is associated with 4 phenotypes. Ubiquitous expression in thyroid (RPKM 5.9), lymph node (RPKM 5.8) and 25 other tissues.

Summary

This gene encodes the enzyme that catalyzes adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

FLAD1 Products (4)

mRNA	Protein	Name
NM_001184891.2	NP_001171820.1	FAD synthase isoform 3
NM_001184892.2	NP_001171821.1	FAD synthase isoform 4
NM_025207.5	NP_079483.3	FAD synthase isoform 1
NM_201398.3	NP_958800.1	FAD synthase isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Références	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FLAD1 Protein Structure

MoCF_biosynth

PAPS_reduct

0
100
200
300
400
500
587 a.a.

Protein Preferred Names	Protein Names
FAD synthase	FAD pyrophosphorylase

FLAD1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	FLAD1	Q8NFF5	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	FLAD1	Q8NFF5	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	FLAD1	Q8NFF5	TCF4	Homo sapiens	P15884	Y2H Prey Pooling	25416956
Intra	FLAD1	Q8NFF5	TCF4	Homo sapiens	P15884	Validated Y2H	25416956
Intra	FLAD1	Q8NFF5	TCF4	Homo sapiens	P15884	Y2H Array	25416956
Intra	FLAD1	Q8NFF5	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	FLAD1	Q8NFF5	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	FLAD1	Q8NFF5	FLAD1	Homo sapiens	Q8NFF5	Y2H Pooling	16189514
Intra	FLAD1	Q8NFF5	FXR1	Homo sapiens	P51114	Y2H Pooling	21653829
Intra	FLAD1	Q8NFF5	FLAD1	Homo sapiens	Q8NFF5	Y2H Array	25416956
Intra	FLAD1	Q8NFF5	CDKN1A	Homo sapiens	P38936	Y2H	21988832
Intra	FLAD1	Q8NFF5	FLAD1	Homo sapiens	Q8NFF5	Y2H Array	31515488

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Lipid Storage Myopathy Due To Flavin Adenine Dinucleotide Synthetase Deficiency	LSMFLAD Lipid Storage Myopathy Due To Flad1 Deficiency Myopathy, Lipid Storage, Due To Flavin Adenine Dinucleotide Synthetase Deficiency
Multiple Acyl-Coa Dehydrogenase Deficiency	MADD Ethylmalonic-Adipicaciduria Ema Glutaric Acidemia Iia Glutaric Acidemia Iib Ga Ii Glutaric Acidemia Iic Glutaric Acidemia Type 2 Glutaric Acidemia Ii Glutaric Aciduria Ii Electron Transfer Flavoprotein Deficiency Glutaric Aciduria Type 2 Mad Deficiency Glutaric Acidemia Type Ii Glutaric Aciduria 2 Etfa Deficiency Etfb Deficiency Etfdh Deficiency Multiple Acyl Coenzyme A Dehydrogenase Deficiency Ga2 Electron Transfer Flavoprotein Ubiquinone Oxidoreductase Deficiency Electron Transfer Flavoprotein Dehydrogenase Deficiency Ga 2 Glutaric Acidemia 2 Glutaric Acidemia, Type 2 Glutaric Aciduria, Type 2 Mad Multiple Fad Dehydrogenase Deficiency Ethylmalonic Adipic Aciduria Glutaricaciduria Ii Glutaric Aciduria 2a GA2A Gaiia Glutaricaciduria Iia Glutaric Aciduria 2b GA2B Gaiib Glutaricaciduria Iib Glutaric Aciduria 2c GA2C Gaiic Glutaricaciduria Iic Glutaricaciduria, Type Iia Glutaric Acidemia Type 2a Glutaric Acidemia Type 2c Glutaric Aciduria Iia Glutaric Aciduria Iib Glutaric Aciduria Iic
Multiple Acyl-Coa Dehydrogenase Deficiency, Mild Type	Glutaric Aciduria Type 2, Mild Type Mad Deficiency, Mild Type Madd, Mild Type
Multiple Acyl-Coa Dehydrogenase Deficiency, Severe Neonatal Type	Glutaric Aciduria Type 2, Severe Neonatal Type Mad Deficiency, Severe Neonatal Type Madd, Severe Neonatal Type
Riboflavin Deficiency	Ariboflavinosis Maternal Riboflavin Deficiency RBFVD Vitamin B2 Deficiency Hyporiboflavinosis
Brown-Vialetto-Van Laere Syndrome
Fazio-Londe Disease	Fazio-Londe Syndrome Riboflavin Transporter Deficiency Neuronopathy Brown-Vialetto-Van Laere Syndrome Progressive Bulbar Palsy Of Childhood Bulbar Palsy, Progressive, Of Childhood Bvvls Pontobulbar Palsy With Deafness Progressive Bulbar Palsy With Sensorineural Deafness Riboflavin Transporter Deficiency FALOND Bulbar Palsy Progressive Of Childhood Bulbar Palsy Of Childhood, Progressive
Progressive Bulbar Palsy	Bulbar Palsy, Progressive Progressive Bulbar Atrophy Bulbar Palsy Pbp - [Progressive Bulbar Palsy] Progressive Bulbar Paralysis Bulbar Paralysis Chronic Bulbar Palsy Chronic Bulbar Paralysis Supranuclear Bulbar Paralysis
Cardiomyopathy, Familial Hypertrophic, 9	Hypertrophic Cardiomyopathy 9 CMH9 Cardiomyopathy, Familial Hypertrophic 9 Cardiomyopathy, Hypertrophic, Familial, Type 9
Mitochondrial Complex I Deficiency, Nuclear Type 20	Acyl-Coa Dehydrogenase 9 Deficiency Acad9 Deficiency MC1DN20 Mitochondrial Complex I Deficiency Due To Acad9 Deficiency Nuclear Type Mitochondrial Complex I Deficiency 20 Acyl-Coa Dehydrogenase Family, Member 9, Deficiency Of Mitochondrial Complex 1 Deficiency Due To Acad9 Deficiency Deficiency Of Acyl-Coa Dehydrogenase Family Member 9 Acyl-Coa Dehydrogenase Family, Member 9, Deficiency
Acyl-Coa Dehydrogenase, Medium-Chain, Deficiency Of	Mcad Deficiency Carnitine Deficiency Secondary To Medium-Chain Acyl-Coa Dehydrogenase Deficiency Acadm Deficiency Acyl-Coa Dehydrogenase, Medium Chain, Deficiency Of Medium Chain Acyl-Coa Dehydrogenase Deficiency ACADMD Mcadh Deficiency Mcadd Medium Chain Acyl-Coenzyme A Dehydrogenase Deficiency Acyl-Coa Dehydrogenase Medium-Chain Deficiency Medium-Chain Acyl-Coenzyme A Dehydrogenase Deficiency Medium Chain Acyl Dehydrogenase Deficiency
Acyl-Coa Dehydrogenase, Very Long-Chain, Deficiency Of	Vlcad Deficiency Very Long Chain Acyl-Coa Dehydrogenase Deficiency Very Long-Chain Acyl-Coenzyme A Dehydrogenase Deficiency Lcad Deficiency Very Long-Chain Acyl-Coa Dehydrogenase Deficiency Long Chain Acyl-Coa Dehydrogenase Deficiency ACADVLD Acadl Deficiency Vlcadd Long-Chain Acyl-Coa Dehydrogenase Deficiency Acadvl Acyl-Coa Dehydrogenase Very Long Chain Deficiency Very Long-Chain Acyl Coenzyme A Dehydrogenase Deficiency Vlcad-C Vlcad-H Acyl-Coa Dehydrogenase, Very Long Chain, Deficiency Of Acyl-Coa Dehydrogenase Very Long-Chain Deficiency Acyl-Coa Dehydrogenase Long-Chain Deficiency Deficiency, Very Long Chain Acyl-Coa Dehydrogenase Long Chain/Very Long Chain Acyl Coa Dehydrogenase Deficiency
Myopathy	Muscular Diseases Myopathies
Mitochondrial Complex I Deficiency, Nuclear Type 1	Mitochondrial Complex I Deficiency Nadh:Q(1) Oxidoreductase Deficiency MC1DN1 Nadh-Coenzyme Q Reductase Deficiency Isolated Mitochondrial Respiratory Chain Complex I Deficiency Isolated Nadh-Coenzyme Q Reductase Deficiency Isolated Nadh-Coq Reductase Deficiency Isolated Nadh-Ubiquinone Reductase Deficiency Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of Nuclear Type Mitochondrial Complex I Deficiency 1 Isolated Complex I Deficiency Complex 1 Mitochondrial Respiratory Chain Deficiency Nadh Coenzyme Q Reductase Deficiency Complex I Mitochondrial Respiratory Chain Deficiency Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I Nadh:Ubiquinone Oxidoreductase Deficiency Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS04973	FLAD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20019	Flad1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26522	Flad1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FLAD1	VGNC	VGNC:107875
Rattus norvegicus	FLAD1	RGD	RGD:1593292
Macaca mulatta	FLAD1	VGNC	VGNC:99952
Canis familiaris	FLAD1	VGNC	VGNC:53481
Mus musculus	FLAD1	MGD	MGI:2443030
Bos taurus	FLAD1	VGNC	VGNC:55191
Others	FLAD1	NCBI