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ZFP91 - ZFP91 zinc finger protein, atypical E3 ubiquitin ligase Gene

Also Known as PZF; DSM8; DMS-8; DSM-8; FKSG11; ZFP-91; ZNF757

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80829

About ZFP91

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:58,579,063-58,621,550 (from NCBI)

This gene has 1 transcript (splice variant), 235 orthologues and 36 paralogues. Broad expression in testis (RPKM 63.1), bone marrow (RPKM 24.8) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010]

ZFP91 Products (2)

mRNA	Protein	Name
NM_001197051.2	NP_001183980.1	E3 ubiquitin-protein ligase ZFP91 isoform 2
NM_053023.5	NP_444251.1	E3 ubiquitin-protein ligase ZFP91 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	20682767	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of NF-kappaB-inducing kinase activity	IDA IDA: Inferred from direct assay	20682767	GOA
involved in protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	20682767	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFP91 Protein Structure

zf-H2C2_2

zf-C2H2

0
100
200
300
400
500
570 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase ZFP91	RING-type E3 ubiquitin transferase ZFP91

ZFP91 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZFP91	Q96JP5	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	ZFP91	Q96JP5	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	ZFP91	Q96JP5	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	ZFP91	Q96JP5	ZNF526	Homo sapiens	Q8TF50	Y2H Array	32296183
Intra	ZFP91	Q96JP5	ZNF526	Homo sapiens	Q8TF50	Y2H Prey Pooling	32296183
Intra	ZFP91	Q96JP5	ZNF526	Homo sapiens	Q8TF50	Validated Y2H	32296183
Intra	ZFP91	Q96JP5	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	32296183
Intra	ZFP91	Q96JP5	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	32296183
Intra	ZFP91	Q96JP5	TP53BP2	Homo sapiens	Q05BL1	Validated Y2H	32296183
Intra	ZFP91	Q96JP5	POU6F2	Homo sapiens	P78424	Validated Y2H	32296183
Intra	ZFP91	Q96JP5	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	ZFP91	Q96JP5	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	ZFP91	Q96JP5	ZFP41	Homo sapiens	Q8N8Y5	Y2H Array	32296183
Intra	ZFP91	Q96JP5	ZFP41	Homo sapiens	Q8N8Y5	Y2H Prey Pooling	32296183
Intra	ZFP91	Q96JP5	ZFP41	Homo sapiens	Q8N8Y5	Validated Y2H	32296183
Intra	ZFP91	Q96JP5	AGR2	Homo sapiens	O95994	Validated Y2H	32296183
Intra	ZFP91	Q96JP5	AGR2	Homo sapiens	O95994	Y2H Prey Pooling	32296183
Intra	ZFP91	Q96JP5	AGR2	Homo sapiens	O95994	Y2H Array	32296183
Intra	ZFP91	Q96JP5	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	32296183
Intra	ZFP91	Q96JP5	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	ZFP91	Q96JP5	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	ZFP91	Q96JP5	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	ZFP91	Q96JP5	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	ZFP91	Q96JP5	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	ZFP91	Q96JP5	FAM9A	Homo sapiens	Q8IZU1	Y2H Prey Pooling	32296183
Intra	ZFP91	Q96JP5	FAM9A	Homo sapiens	Q8IZU1	Validated Y2H	32296183
Intra	ZFP91	Q96JP5	FAM9A	Homo sapiens	Q8IZU1	Y2H Array	32296183
Intra	ZFP91	Q96JP5	TSPYL2	Homo sapiens	Q9H2G4	Y2H Prey Pooling	32296183
Intra	ZFP91	Q96JP5	TSPYL2	Homo sapiens	Q9H2G4	Y2H Array	32296183
Intra	ZFP91	Q96JP5	TSPYL2	Homo sapiens	Q9H2G4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

ZFP91 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84732	ZFP91 Antibody (YA4429)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P84732A	ZFP91 Antibody (YA4429)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Duane-Radial Ray Syndrome	Okihiro Syndrome DRRS Dr Syndrome Duane Anomaly With Radial Ray Abnormalities And Deafness Acrorenoocular Syndrome Acrorenocular Syndrome Duane Anomaly With Radial Abnormalities And Deafness Acro-Renal-Ocular Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153698	CC-3060		99.7%	Unkown
HY-177725	MG degrader 2	Degrader	/	Unkown
HY-RS16046	ZFP91 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZFP91	MGD	MGI:104854
Rattus norvegicus	ZFP91	RGD	RGD:628736
Macaca mulatta	ZFP91	VGNC	VGNC:101428