Dnajb1 - DnaJ heat shock protein family (Hsp40) member B1 Gene

Also Known as DjB1; Hdj1; HSPF1; Hsp40; 0610007I11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 81489

About Dnajb1

Chromosome 8: 84,334,822-84,339,282 forward strand.GRCm39:CM001001.3

This gene has 2 transcripts (splice variants), 432 orthologues, 13 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis adult (RPKM 83.7), thymus adult (RPKM 27.3) and 28 other tissues.

Summary

This gene encodes a member of the DnaJ or HSP40 (heat shock protein 40 kD) family of proteins. The encoded protein is a molecular chaperone that stimulates the ATPase activity of HSP70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. The encoded protein may also inhibit Apoptosis. Peritoneal macrophages derived from homozygous knockout mice for this gene exhibit impaired heat tolerance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Dnajb1 Products (2)

mRNA Protein Name
NM_001308227.1 NP_001295156.1 dnaJ homolog subfamily B member 1 isoform 2
NM_018808.3 NP_061278.1 dnaJ homolog subfamily B member 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein folding chaperone IDA
IDA: Inferred from direct assay
27496612 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chaperone cofactor-dependent protein refolding IGI
IGI: Inferred from genetic interaction
14644449 MGI
involved in protein folding IDA
IDA: Inferred from direct assay
27496612 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Dnajb1 Protein Structure

DnaJ

DnaJ: COG0484 (0 - 339)

  • 0
  • 100
  • 200
  • 300
  • 340 a.a.
Protein Preferred Names Protein Names

dnaJ homolog subfamily B member 1

  • DnaJ (Hsp40) homolog, subfamily B, member 1

  • heat shock 40 kDa protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150072 DS89002333 Inhibitor 99.85% Unkown
HY-RS03861 DNAJB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-114461B (3S,17S)-FD-895 / Unkown
HY-RS03862 Dnajb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03863 Dnajb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dnajb1 NCBI NCBI:3337