DNAJB1 - DnaJ heat shock protein family (Hsp40) member B1 Gene

Also Known as Hdj1; Sis1; HSPF1; Hsp40; RSPH16B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3337

About DNAJB1

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:14,514,769-14,560,391 (from NCBI)

This gene has 25 transcripts (splice variants), 425 orthologues, 11 paralogues and is associated with 55 phenotypes. Ubiquitous expression in esophagus (RPKM 87.8), adrenal (RPKM 84.6) and 24 other tissues.

Summary

This gene encodes a member of the DnaJ or HSP40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. The encoded protein is a molecular chaperone that stimulates the ATPase activity of HSP70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

DNAJB1 Products (7)

mRNA	Protein	Name
XM_011527956.4	XP_011526258.1	dnaJ homolog subfamily B member 1 isoform X1
NM_006145.3	NP_006136.1	dnaJ homolog subfamily B member 1 isoform 1
NM_001300914.2	NP_001287843.1	dnaJ homolog subfamily B member 1 isoform 2
NM_001313964.2	NP_001300893.1	dnaJ homolog subfamily B member 1 isoform 2
XM_047438746.1	XP_047294702.1	dnaJ homolog subfamily B member 1 isoform X1
XM_006722733.3	XP_006722796.1	dnaJ homolog subfamily B member 1 isoform X1
XM_047438745.1	XP_047294701.1	dnaJ homolog subfamily B member 1 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATPase activator activity	IDA IDA: Inferred from direct assay	20060297	GOA
enables ATPase binding	IPI IPI: Inferred from physical interaction	23921388	GOA
enables Hsp70 protein binding	IPI IPI: Inferred from physical interaction	23921388	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9499401	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	21231916	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	9499401	GOA
enables transcription regulator inhibitor activity	IDA IDA: Inferred from direct assay	9499401	GOA
enables unfolded protein binding	IDA IDA: Inferred from direct assay	21231916	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to heat	IDA IDA: Inferred from direct assay	9499401	GOA
involved in chaperone cofactor-dependent protein refolding	IDA IDA: Inferred from direct assay	18620420	GOA
involved in negative regulation of inclusion body assembly	IDA IDA: Inferred from direct assay	21231916	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9499401	GOA
involved in positive regulation of ATP-dependent activity	IDA IDA: Inferred from direct assay	23921388	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	25468996	GOA
located in cytosol	IDA IDA: Inferred from direct assay	21231916	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJB1 Protein Structure

DnaJ

DnaJ_C

0
100
200
300
340 a.a.

Protein Preferred Names	Protein Names
dnaJ homolog subfamily B member 1	DnaJ (Hsp40) homolog, subfamily B, member 1 dnaJ protein homolog 1 heat shock 40 kDa protein 1 human DnaJ protein 1 radial spoke 16 homolog B

DNAJB1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DNAJB1	P25685	TBL1X	Homo sapiens	O60907-2	Y2H Pooling	32814053
Intra	DNAJB1	P25685	TBL1X	Homo sapiens	O60907-2	Validated Y2H	32814053
Intra	DNAJB1	P25685	TBL1X	Homo sapiens	O60907-2	Y2H Array	32814053
Intra	DNAJB1	P25685	UNG	Homo sapiens	P13051-2	Validated Y2H	32814053
Intra	DNAJB1	P25685	UNG	Homo sapiens	P13051-2	Y2H Pooling	32814053
Intra	DNAJB1	P25685	UNG	Homo sapiens	P13051-2	Y2H Array	32814053
Intra	DNAJB1	P25685	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	35271311
Intra	DNAJB1	P25685	CDC37	Homo sapiens	Q16543	Y2H Array	21163940
Intra	DNAJB1	P25685	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	DNAJB1	P25685	TFF2	Homo sapiens	Q03403	Y2H Pooling	32814053
Intra	DNAJB1	P25685	TFF2	Homo sapiens	Q03403	Validated Y2H	32814053
Intra	DNAJB1	P25685	TFF2	Homo sapiens	Q03403	Y2H Array	32814053
Intra	DNAJB1	P25685	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	DNAJB1	P25685	TTLL12	Homo sapiens	Q14166	Anti Tag CoIP	33961781
Intra	DNAJB1	P25685	TTLL12	Homo sapiens	Q14166	Anti Tag CoIP	28514442
Intra	DNAJB1	P25685	TTLL12	Homo sapiens	Q14166	Validated Y2H	32296183
Intra	DNAJB1	P25685	TTLL12	Homo sapiens	Q14166	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DNAJB1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70331	HSP40/DNAJB1 Protein, Human (His)	P25685-1 (G2-I340)	≥ 95%, as determined by reducing SDS-PAGE.

DNAJB1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80710	Hsp40 Antibody (YA731)	WB	Human
HY-P80710A	Hsp40 Antibody (YA731)(PBS only)	WB	Human
HY-P85703	Hsp40 Antibody (YA5395)	IHC-P, WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Fibrolamellar Carcinoma	Fibrolamellar Hepatocellular Carcinoma Fhcc Fibrolamellar Hepatocarcinoma Hepatocellular Carcinoma, Fibrolamellar Oncocytic Hepatocellular Tumor Eosinophilic Glassy Cell Hepatoma Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis Fl-Hcc Fibrolamellar Oncocytic Hepatoma Hepatocellular Carcinoma With Increased Stromal Fibrosis Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Transvestism	Dual-Role Transvestism Fetishistic Transvestism Cross Dresser Transvestic Fetishism
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Polyhydramnios
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Creutzfeldt-Jakob Disease	Variant Creutzfeldt-Jakob Disease CJD Bovine Spongiform Encephalopathy Vcjd Inherited Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease, Familial Creutzfeldt Jakob Disease Creutzfeldt-Jacob Disease Creutzfeldt Jacob Disease Sporadic Creutzfeldt-Jakob Disease Encephalopathy, Bovine Spongiform Creutzfeldt-Jakob Disease, Variant, Resistance To Creutzfeldt-Jakob Disease, Variant Creutzfeldt Jacob Syndrome Jakob-Creutzfeldt Disease Subacute Spongiform Encephalopathy Transmissible Virus Dementia New Variant Of Cjd Nv-Cjd Variant Cjd Variant Creutzfeldt-Jacob Disease Sporadic Cjd Inherited Cjd Acquired Creutzfeldt-Jakob Disease Variant Mcj Encephalopathy Bovine Spongiform Familial Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Syndrome New Variant Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease, Sporadic Acquired Cjd Scjd - [Sporadic Creutzfeldt-Jakob Disease] Idiopathic Creutzfeldt-Jakob Disease Creutzfeld-Jakob Disease Nos Vcjd - [Variant Creutzfeldt-Jakob Disease]
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias
Spinal Muscular Atrophy	Sma 5q Sma Proximal Sma Sma-Associated Sma Spinal Amyotrophies Spinal Amyotrophy Spinal Muscle Degeneration Spinal Muscle Wasting Muscular Atrophy Spinal Atrophy, Muscular, Spinal Hereditary Motor Neuronopathy Progressive Muscular Atrophy Sma - [Spinal Muscular Atrophy]
Muscular Dystrophy, Limb-Girdle, Autosomal Dominant 1	Muscular Dystrophy, Limb-Girdle, Type 1e Lgmd1d Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1d LGMDD1 Lgmd1e Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1 Limb-Girdle Muscular Dystrophy Type 1d Muscular Dystrophy, Limb-Girdle, Type 1d Muscular Dystrophy, Limb-Girdle, Type 1d, Formerly Lgmd1d, Formerly Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1e Muscular Dystrophy Limb-Girdle Type 1d Muscular Dystrophy Limb-Girdle Type 1e Dnajb6-Related Limb-Girdle Muscular Dystrophy D1 Dnajb6-Related Lgmd D1 Lgmd Type 1d Limb-Girdle Muscular Dystrophy 1e Limb-Girdle Muscular Dystrophy-1d, Autosomal Dominant Dystrophy, Muscular, Limb-Girdle, Autosomal Dominant, Type 1 Dystrophy, Muscular, Limb-Girdle, Type 1e
Craniotubular Dysplasia, Ikegawa Type	CTDI Craniotubular Dysplasia Ikegawa Type Doid:0112340
Spinal And Bulbar Muscular Atrophy, X-Linked 1	Kennedy Disease Sbma Spinal And Bulbar Muscular Atrophy Kennedy'S Disease X-Linked Spinal And Bulbar Muscular Atrophy SMAX1 Kd Kennedy Spinal And Bulbar Muscular Atrophy Spinobulbar Muscular Atrophy Bulbospinal Muscular Atrophy, X-Linked Bulbospinal Neuronopathy, X-Linked Recessive Xbsn Spinal And Bulbar Muscular Atrophy Of Kennedy Bulbospinal Muscular Atrophy X-Linked Bulbospinal Amyotrophy Bulbo-Spinal Atrophy, X-Linked Spinal Bulbar Muscular Atrophy X-Linked Bulbo-Spinal Atrophy X-Linked Spinal Bulbar Muscular Atrophy X-Linked Bsma X-Linked Bulbospinal Muscular Atrophy Spinal And Bulbar Muscular Atrophy X-Linked 1 Bulbospinal Muscular Atrophy X-Linked Bulbospinal Neuronopathy X-Linked Recessive Kennedy Disease) Kennedy Syndrome Atrophy, Muscular, Spinal And Bulbar, Kennedy Type Atrophy, Muscular, Spinobulbar Bulbospinal Neuronopathy
Mixed Fibrolamellar Hepatocellular Carcinoma
Retinitis Pigmentosa 58	RP58 Retinitis Pigmentosa, Type 58
Craniodiaphyseal Dysplasia	Schaefer Stein Oshman Syndrome CDD Craniodiaphyseal Dysplasia, Dominant Dominantly Inherited Craniodiaphyseal Dysplasia
Autosomal Dominant Limb-Girdle Muscular Dystrophy	Muscular Dystrophy, Limb-Girdle, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150072	DS89002333	Inhibitor	99.85%	Unkown
HY-RS03861	DNAJB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-114461B	(3S,17S)-FD-895		/	Unkown
HY-RS03862	Dnajb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03863	Dnajb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DNAJB1	VGNC	VGNC:78440
Rattus norvegicus	DNAJB1	RGD	RGD:1304725
Macaca mulatta	DNAJB1	VGNC	VGNC:109616
Canis familiaris	DNAJB1	VGNC	VGNC:54594
Mus musculus	DNAJB1	MGD	MGI:1931874
Others	DNAJB1	NCBI