Pi4kb - phosphatidylinositol 4-kinase beta Gene

Also Known as Pik4cb

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81747

About Pi4kb

Primary_assembly 2: 182,540,567-182,588,488 forward strand.mRatBN7.2:CM026975.1

This gene has 6 transcripts (splice variants), 213 orthologues, 9 paralogues and is associated with 8 phenotypes. Biased expression in Adrenal (RPKM 175.8), Kidney (RPKM 157.8) and 9 other tissues.

Summary

Enables 1-phosphatidylinositol 4-kinase activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and phosphatidylinositol-mediated signaling. Located in cytosol and plasma membrane. Orthologous to human PI4KB (phosphatidylinositol 4-kinase beta). [provided by Alliance of Genome Resources, Apr 2022]

Pi4kb Products (2)

mRNA Protein Name
NM_031083.2 NP_112345.1 phosphatidylinositol 4-kinase beta
NM_031083.2 NP_112345.1 phosphatidylinositol 4-kinase beta

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables 1-phosphatidylinositol 4-kinase activity IDA
IDA: Inferred from direct assay
8973579 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12244129 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pi4kb Protein Structure

PI4KB_NTD

PI4KB_NTD: cd22246 (26 - 90)

PI4Kc_III_beta

PI4Kc_III_beta: cd05168 (553 - 861)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 862 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 4-kinase beta

  • PI4K-beta

  • PI4Kbeta

  • catalytic phosphatidylinositol 4-kinase beta

  • phosphatidylinositol 4-kinase, catalytic, beta polypeptide

  • ptdIns 4-kinase beta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100603 GSK-F1 Inhibitor 95.06% Unkown
HY-108313 T-00127_HEV1 Inhibitor 99.97% Unkown
HY-22055B AN-12-H5 intermediate-1 99.72% Unkown
HY-W047496 AN-12-H5 intermediate-2 97.0% Unkown
HY-120900 AN-12-H5 Inhibitor 98.03% Unkown
HY-RS10470 Pi4kb Mouse Pre-designed siRNA Set A / Unkown
HY-177725 MG degrader 2 Degrader / Unkown
HY-182721 Pipinib / Unkown
HY-RS10469 PI4KB Human Pre-designed siRNA Set A / Unkown
HY-RS10471 Pi4kb Rat Pre-designed siRNA Set A / Unkown
HY-100603B (R)-GSK-F1 Inhibitor / Unkown
HY-175557 PI4K-IN-2 Inhibitor / Unkown
HY-W451820 AN-12-H5 intermediate-3 95.82% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pi4kb NCBI NCBI:5298