Rps6ka1 - ribosomal protein S6 kinase A1 Gene

Also Known as S6K-alpha 1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81771

About Rps6ka1

Primary_assembly 5: 146,079,021-146,118,272 reverse strand.mRatBN7.2:CM026978.1

This gene has 4 transcripts (splice variants), 218 orthologues, 7 paralogues and is associated with 2 phenotypes. Biased expression in Spleen (RPKM 156.7), Thymus (RPKM 113.2) and 9 other tissues.

Summary

Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein serine/threonine/tyrosine kinase activity; and ribosomal protein S6 kinase activity. Involved in positive regulation of transcription, DNA-templated and protein phosphorylation. Located in cytoplasm and nucleus. Orthologous to human RPS6KA1 (ribosomal protein S6 kinase A1). [provided by Alliance of Genome Resources, Apr 2022]

Rps6ka1 Products (2)

mRNA Protein Name
NM_031107.2 NP_112369.2 ribosomal protein S6 kinase alpha-1
NM_031107.2 NP_112369.2 ribosomal protein S6 kinase alpha-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15117958 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12213813 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
12213813 RGD
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
10517950 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
10517950 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rps6ka1 Protein Structure

STKc_RSK_N

STKc_RSK_N: cd05582 (71 - 387)

STKc_RSK1_C

STKc_RSK1_C: cd14175 (421 - 711)

  • 0
  • 200
  • 400
  • 600
  • 741 a.a.
Protein Preferred Names Protein Names

ribosomal protein S6 kinase alpha-1

  • 90 kDa ribosomal protein S6 kinase 1

  • MAP kinase-activated protein kinase 1a

  • MAPK-activated protein kinase 1a

  • MAPKAP kinase 1a

  • MAPKAPK-1a

  • MAPKAPK1A

  • RSK-1

  • S6 protein kinase (Rsk-1)

  • S6K-alpha-1

  • p90-RSK 1

  • p90RSK1

  • p90S6K

  • pp90RSK1

  • ribosomal S6 kinase 1

  • ribosomal protein S6 kinase polypeptide 1

  • ribosomal protein S6 kinase, polypeptide A1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-123919 TL13-112 Inhibitor 98.01% Unkown
HY-122582 TL13-12 Degrader 98.16% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 99.92% Unkown
HY-136194 TL13-22 Inhibitor 99.71% Unkown
HY-136195 TL13-110 Inhibitor / Unkown
HY-RS12248 RPS6KA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12249 Rps6ka1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12250 Rps6ka1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rps6ka1 NCBI NCBI:6195