Lamtor2 - late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Gene

Also Known as P14; Rab25; Robld3; Mapbpip; 2010111E04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 83409

Summary

Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Acts upstream of or within several processes, including fibroblast migration; positive regulation of MAPK cascade; and regulation of cell-substrate junction organization. Located in late endosome. Orthologous to human LAMTOR2 (late endosomal/lysosomal adaptor, MAPK and mTOR Activator 2). [provided by Alliance of Genome Resources, Apr 2022]

Lamtor2 Products (2)

mRNA Protein Name
NM_001362368.1 NP_001349297.1 ragulator complex protein LAMTOR2 isoform 2
NM_031248.4 NP_112538.1 ragulator complex protein LAMTOR2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15263099 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within fibroblast migration IDA
IDA: Inferred from direct assay
24841562 MGI
acts upstream of or within fibroblast migration IGI
IGI: Inferred from genetic interaction
24841562 MGI
acts upstream of or within fibroblast migration IMP
IMP: Inferred from mutant phenotype
24841562 MGI
acts upstream of or within positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
15263099 MGI
acts upstream of or within protein localization to cell junction IMP
IMP: Inferred from mutant phenotype
24841562 MGI
acts upstream of or within regulation of cell-substrate junction organization IDA
IDA: Inferred from direct assay
24841562 MGI
acts upstream of or within regulation of cell-substrate junction organization IMP
IMP: Inferred from mutant phenotype
24841562 MGI
Cellular Component GO Annotation Evidence References Source
located in late endosome IDA
IDA: Inferred from direct assay
15263099 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ragulator complex protein LAMTOR2

  • endosomal adaptor protein p14

  • late endosomal/lysosomal MP1 interacting protein

  • late endosomal/lysosomal adaptor and MAPK and MTOR activator 2

  • mitogen-activated protein-binding protein-interacting protein

  • roadblock domain-containing protein 3

Lamtor2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Lamtor2 Q9JHS3 Lamtor3 Mus musculus O88653
X-Ray Diffraction
15263099
Cross
Lamtor2 Q9JHS3 Lamtor1 Rattus norvegicus Q6P791
IF
19177150
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07514 LAMTOR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19544 Lamtor2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26040 Lamtor2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lamtor2 NCBI NCBI:28956