Ppargc1a - PPARG coactivator 1 alpha Gene

Also Known as PGCvf; LRPGC1; PGC-1v; PGCvf1; PGCvf-1; Ppargc1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83516

About Ppargc1a

Primary_assembly 14: 58,861,144-59,512,656 forward strand.mRatBN7.2:CM026987.1

This gene has 4 transcripts (splice variants), 206 orthologues, 2 paralogues and is associated with 65 phenotypes. Biased expression in Kidney (RPKM 186.), Heart (RPKM 141.9) and 7 other tissues.

Summary

Enables several functions, including alpha-tubulin binding activity; Estrogen receptor binding activity; and peroxisome proliferator activated receptor binding activity. Involved in several processes, including cellular response to hexose stimulus; cellular response to organic cyclic compound; and regulation of smooth muscle cell proliferation. Located in several cellular components, including apical dendrite; cytosolic ribosome; and euchromatin. Used to study several diseases, including fatty liver disease (multiple); glucose metabolism disease (multiple); heart disease (multiple); neurodegenerative disease (multiple); and sciatic neuropathy. Biomarker of several diseases, including Huntington's disease; glucose metabolism disease (multiple); placental insufficiency; primary biliary cholangitis; and renal fibrosis. Human ortholog(s) of this gene implicated in several diseases, including macular degeneration; malignant fibrous histiocytoma; neurodegenerative disease (multiple); non-alcoholic fatty liver disease; and type 2 diabetes mellitus. Orthologous to human PPARGC1A (PPARG coactivator 1 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Ppargc1a Products (2)

mRNA Protein Name
NM_031347.1 NP_112637.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha
NM_031347.1 NP_112637.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alpha-tubulin binding IDA
IDA: Inferred from direct assay
23297307 RGD
enables chromatin binding IDA
IDA: Inferred from direct assay
22705949 RGD
enables nuclear estrogen receptor binding IPI
IPI: Inferred from physical interaction
18511507 RGD
enables peroxisome proliferator activated receptor binding IPI
IPI: Inferred from physical interaction
22464285 RGD
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
19948729 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
19940161 RGD
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
12107181 RGD
Biological Process GO Annotation Evidence References Source
involved in adaptive thermogenesis IEP
IEP: Inferred from expression pattern
20363363 RGD
involved in androgen metabolic process IEP
IEP: Inferred from expression pattern
23338851 RGD
involved in autophagy of mitochondrion IEP
IEP: Inferred from expression pattern
19783904 RGD
involved in cellular response to caffeine IEP
IEP: Inferred from expression pattern
17516843 RGD
involved in cellular response to estradiol stimulus IEP
IEP: Inferred from expression pattern
19786068 RGD
involved in cellular response to fatty acid IEP
IEP: Inferred from expression pattern
22676303 RGD
involved in cellular response to follicle-stimulating hormone stimulus IDA
IDA: Inferred from direct assay
18511507 RGD
involved in cellular response to fructose stimulus IEP
IEP: Inferred from expression pattern
21212096 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
23692924 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
22527940 RGD
involved in cellular response to interleukin-6 IEP
IEP: Inferred from expression pattern
23692924 RGD
involved in cellular response to ionomycin IEP
IEP: Inferred from expression pattern
17516843 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
19853624 RGD
involved in cellular response to nitrite IEP
IEP: Inferred from expression pattern
22892143 RGD
involved in cellular response to potassium ion IEP
IEP: Inferred from expression pattern
17870059 RGD
involved in cellular response to resveratrol IEP
IEP: Inferred from expression pattern
20438809 RGD
involved in cellular response to thyroid hormone stimulus IDA
IDA: Inferred from direct assay
19948729 RGD
involved in cellular response to thyroid hormone stimulus IEP
IEP: Inferred from expression pattern
23209300 RGD
involved in cellular response to transforming growth factor beta stimulus IDA
IDA: Inferred from direct assay
18511507 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
22343369 RGD
involved in cerebellum development IEP
IEP: Inferred from expression pattern
17335037 RGD
involved in fatty acid oxidation IEP
IEP: Inferred from expression pattern
17869249 RGD
involved in flavone metabolic process IEP
IEP: Inferred from expression pattern
22767158 RGD
involved in forebrain development IEP
IEP: Inferred from expression pattern
17335037 RGD
involved in galactose metabolic process IEP
IEP: Inferred from expression pattern
23022596 RGD
involved in gluconeogenesis IEP
IEP: Inferred from expression pattern
21212096 RGD
involved in mitochondrion organization IEP
IEP: Inferred from expression pattern
21543634 RGD
involved in mitochondrion organization IMP
IMP: Inferred from mutant phenotype
17099248 RGD
involved in negative regulation of glycolytic process IMP
IMP: Inferred from mutant phenotype
22343369 RGD
involved in negative regulation of mitochondrial fission IMP
IMP: Inferred from mutant phenotype
23449689 RGD
involved in negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
19786068 RGD
involved in negative regulation of signaling receptor activity IMP
IMP: Inferred from mutant phenotype
22593067 RGD
involved in negative regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
19142226 RGD
involved in negative regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
19142226 RGD
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
16139565 RGD
involved in positive regulation of fatty acid oxidation IMP
IMP: Inferred from mutant phenotype
16139565 RGD
involved in positive regulation of podocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
23692924 RGD
involved in positive regulation of progesterone biosynthetic process IMP
IMP: Inferred from mutant phenotype
20133449 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20133449 RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
22527940 RGD
involved in regulation of NMDA receptor activity IMP
IMP: Inferred from mutant phenotype
22593067 RGD
involved in response to L-leucine IEP
IEP: Inferred from expression pattern
22612562 RGD
involved in response to activity IDA
IDA: Inferred from direct assay
19273580 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
20433743 RGD
involved in response to dehydroepiandrosterone IEP
IEP: Inferred from expression pattern
22523357 RGD
involved in response to electrical stimulus IEP
IEP: Inferred from expression pattern
20375275 RGD
involved in response to electrical stimulus involved in regulation of muscle adaptation IEP
IEP: Inferred from expression pattern
15716393 RGD
involved in response to epinephrine IEP
IEP: Inferred from expression pattern
19221126 RGD
involved in response to fructose IEP
IEP: Inferred from expression pattern
23269653 RGD
involved in response to hypobaric hypoxia IEP
IEP: Inferred from expression pattern
22523357 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
20875806 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
21302669 RGD
involved in response to methionine IEP
IEP: Inferred from expression pattern
17716000 RGD
involved in response to muscle activity IEP
IEP: Inferred from expression pattern
23462817 RGD
involved in response to norepinephrine IEP
IEP: Inferred from expression pattern
23443926 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
26394137 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
22773756 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
23104933 RGD
involved in response to reactive oxygen species IEP
IEP: Inferred from expression pattern
16916551 RGD
involved in response to starvation IEP
IEP: Inferred from expression pattern
22117073 RGD
involved in response to thyroid hormone IEP
IEP: Inferred from expression pattern
15605382 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
22343369 RGD
involved in skeletal muscle atrophy IEP
IEP: Inferred from expression pattern
16870628 RGD
Cellular Component GO Annotation Evidence References Source
located in apical dendrite IDA
IDA: Inferred from direct assay
17335037 RGD
located in cytosolic ribosome IDA
IDA: Inferred from direct assay
17870059 RGD
located in euchromatin IDA
IDA: Inferred from direct assay
17870059 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
17335037 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ppargc1a Protein Structure

RRM_PPARGC1A

RRM_PPARGC1A: cd12623 (707 - 797)

  • 0
  • 200
  • 400
  • 600
  • 831 a.a.
Protein Preferred Names Protein Names

peroxisome proliferator-activated receptor gamma coactivator 1-alpha

  • PGC-1-alpha

  • PGC-1alpha

  • PPAR gamma coactivator 1alpha variant form-1

  • PPAR-gamma coactivator 1-alpha

  • PPARGC-1-alpha

  • Ppargc1a-vf1

  • peroxisome proliferative activated receptor gamma coactivator 1

  • peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10930 Ppargc1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10928 PPARGC1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10929 Ppargc1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppargc1a NCBI NCBI:10891