Nfe2l2 - NFE2 like bZIP transcription factor 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83619

About Nfe2l2

Primary_assembly 3: 60,594,242-60,621,737 reverse strand.mRatBN7.2:CM026976.1

This gene has 3 transcripts (splice variants), 218 orthologues, 3 paralogues and is associated with 109 phenotypes. Biased expression in Liver (RPKM 314.7), Adrenal (RPKM 35.6) and 9 other tissues.

Summary

Enables transcription cis-regulatory region binding activity and transcription coregulator binding activity. Involved in several processes, including aflatoxin catabolic process; positive regulation of macromolecule metabolic process; and regulation of cell migration. Located in cytoplasm and nucleus. Used to study several diseases, including diabetic retinopathy; liver cirrhosis; middle cerebral artery infarction; non-alcoholic fatty liver disease; and visual epilepsy. Biomarker of several diseases, including extrahepatic cholestasis; kidney failure (multiple); neurodegenerative disease (multiple); non-alcoholic steatohepatitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; macular degeneration; and tuberculosis. Orthologous to human NFE2L2 (NFE2 like bZIP transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Nfe2l2 Products (2)

mRNA Protein Name
NM_031789.3 NP_113977.1 nuclear factor erythroid 2-related factor 2 isoform 2
NM_001399173.1 NP_001386102.1 nuclear factor erythroid 2-related factor 2 isoform 1

Nfe2l2 Protein Structure

bZIP_NFE2-like

bZIP_NFE2-like: cd14720 (492 - 559)

bZIP_NFE2-like

bZIP_NFE2-like: cd14720 (493 - 555)

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  • 500
  • 604 a.a.
Protein Preferred Names Protein Names

nuclear factor erythroid 2-related factor 2

  • NF-E2-related factor 2

  • NFE2-related factor 2

  • nrf2

  • nuclear factor, erythroid 2-like 2

  • nuclear factor, erythroid derived 2, like 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12213 CDDO-EA Activator 99.78% Unkown
HY-RS09245 NFE2L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09246 Nfe2l2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-145390 Nrf2 activator-1 Activator 98.66% Unkown
HY-145390A (R,R)-Nrf2 activator-1 Activator 96.88% Unkown
HY-177944 DC-PGKI / Unkown
HY-RS09247 Nfe2l2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-125995 NFE2L2 activator 3 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nfe2l2 NCBI NCBI:4780