STARD3NL - STARD3 N-terminal like Gene

Also Known as MENTHO

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83930

About STARD3NL

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:38,178,245-38,230,669 (from NCBI)

This gene has 7 transcripts (splice variants), 219 orthologues and 5 paralogues. Ubiquitous expression in prostate (RPKM 17.0), placenta (RPKM 15.5) and 25 other tissues.

Summary

This gene encodes a late-endosomal protein that contains a conserved MENTAL (MLN64 N-terminal) domain. The encoded protein binds Cholesterol molecules and may play a role in endosomal Cholesterol transport through interactions with metastatic lymph node protein 64 (MLN64). [provided by RefSeq, Sep 2011]

STARD3NL Products (8)

mRNA Protein Name
NM_001363339.2 NP_001350268.1 STARD3 N-terminal-like protein isoform 1
NM_001363340.2 NP_001350269.1 STARD3 N-terminal-like protein isoform 1
NM_001363343.2 NP_001350272.1 STARD3 N-terminal-like protein isoform 2
NM_001363344.2 NP_001350273.1 STARD3 N-terminal-like protein isoform 2
NM_001363345.2 NP_001350274.1 STARD3 N-terminal-like protein isoform 2
NM_001363346.2 NP_001350275.1 STARD3 N-terminal-like protein isoform 2
NM_001363347.2 NP_001350276.1 STARD3 N-terminal-like protein isoform 2
NM_032016.4 NP_114405.1 STARD3 N-terminal-like protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cholesterol binding IDA
IDA: Inferred from direct assay
15718238 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15718238 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
15718238 GOA
Biological Process GO Annotation Evidence References Source
involved in vesicle tethering to endoplasmic reticulum IDA
IDA: Inferred from direct assay
24105263 GOA
Cellular Component GO Annotation Evidence References Source
colocalizes with endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
24105263 GOA
located in endoplasmic reticulum-endosome membrane contact site IDA
IDA: Inferred from direct assay
24105263 GOA
located in endosome IDA
IDA: Inferred from direct assay
29858488 GOA
located in late endosome membrane IDA
IDA: Inferred from direct assay
24105263 GOA
located in organelle membrane contact site IDA
IDA: Inferred from direct assay
24105263 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STARD3NL Protein Structure

MENTAL

MENTAL: Cholesterol-capturing domain (49 - 215)

  • 0
  • 100
  • 200
  • 234 a.a.
Protein Preferred Names Protein Names

STARD3 N-terminal-like protein

  • MLN64 N-terminal domain homolog

STARD3NL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STARD3NL O95772 HCST Homo sapiens Q9UBK5
Y2H Prey Pooling
32296183
Intra
STARD3NL O95772 HCST Homo sapiens Q9UBK5
Validated Y2H
32296183
Intra
STARD3NL O95772 HCST Homo sapiens Q9UBK5
Y2H Array
32296183
Intra
STARD3NL O95772 MOSPD2 Homo sapiens Q8NHP6
Anti Tag CoIP
29858488
Intra
STARD3NL O95772 MOSPD2 Homo sapiens Q8NHP6
Pull Down
29858488
Intra
STARD3NL O95772 MOSPD2 Homo sapiens Q8NHP6
Anti Tag CoIP
33961781
Intra
STARD3NL O95772 MOSPD2 Homo sapiens Q8NHP6
Confocal
29858488
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Immunodeficiency 51

  • IMD51

  • Candf5

  • Candidiasis, Familial, 5

  • Candidiasis, Familial, 5, Formerly

  • Candf5, Formerly

  • Familial Candidiasis 5

  • Candidiasis Familial 5 Autosomal Recessive

  • Candidiasis Familial Chronic Mucocutaneous Autosomal Recessive

  • Chronic Mucocutaneous Candidiasis 5
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13879 STARD3NL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus STARD3NL VGNC VGNC:35364
Canis familiaris STARD3NL VGNC VGNC:46883
Macaca mulatta STARD3NL VGNC VGNC:84755
Felis catus STARD3NL VGNC VGNC:65754
Rattus norvegicus STARD3NL RGD RGD:1308633
Mus musculus STARD3NL MGD MGI:1923455
Others STARD3NL NCBI