PIP4K2B - phosphatidylinositol-5-phosphate 4-kinase type 2 beta Gene

Also Known as PI5P4KB; PIP5K2B; PIP5KIIB; PIP5P4KB; PIP5KIIbeta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8396

About PIP4K2B

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:38,765,691-38,799,556 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 191 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 40.4), ovary (RPKM 23.8) and 24 other tissues.

Summary

The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to Other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF Receptor. [provided by RefSeq, Jul 2008]

PIP4K2B Products (1)

mRNA Protein Name
NM_003559.5 NP_003550.1 phosphatidylinositol 5-phosphate 4-kinase type-2 beta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IDA
IDA: Inferred from direct assay
9038203 GOA
enables ATP binding IDA
IDA: Inferred from direct assay
26774281 GOA
enables GTP binding IDA
IDA: Inferred from direct assay
26774281 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
9753329 GOA
Biological Process GO Annotation Evidence References Source
involved in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process IDA
IDA: Inferred from direct assay
26774281 GOA
involved in negative regulation of insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
31091439 GOA
involved in positive regulation of autophagosome assembly IMP
IMP: Inferred from mutant phenotype
25578879 GOA
involved in regulation of autophagy IMP
IMP: Inferred from mutant phenotype
25578879 GOA
Cellular Component GO Annotation Evidence References Source
located in autophagosome IMP
IMP: Inferred from mutant phenotype
25578879 GOA
located in nucleus IDA
IDA: Inferred from direct assay
30718367 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
30718367 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIP4K2B Protein Structure

PIP5K

PIP5K: Phosphatidylinositol-4-phosphate 5-Kinase (129 - 414)

  • 0
  • 100
  • 200
  • 300
  • 416 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 5-phosphate 4-kinase type-2 beta

  • 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta

Recombinant PIP4K2B Proteins

Cat. No. Product Name Accession Purity
HY-P700597 PIP4K2B Protein, Human (His) P78356 (S2-T416) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Developmental And Epileptic Encephalopathy 33

  • DEE33

  • Epileptic Encephalopathy, Early Infantile, 33

  • Eiee33

  • Developmental And Epileptic Encephalopathy, 33

  • Early Infantile Epileptic Encephalopathy 33

  • Encephalopathy, Epileptic, Early Infantile, Type 33
Cone-Rod Dystrophy 5

  • CORD5

  • Dystrophy, Cone-Rod, Type 5
Lateral Meningocele Syndrome

  • Lehman Syndrome

  • Lms

  • LMNS

  • Meningocele, Lateral Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-177432 TMX-4140 Inhibitor / Unkown
HY-183627 066ATZ Inhibitor / Unkown
HY-RS10563 PIP4K2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PIP4K2B VGNC VGNC:32907
Macaca mulatta PIP4K2B VGNC VGNC:76004
Rattus norvegicus PIP4K2B RGD RGD:621710
Felis catus PIP4K2B VGNC VGNC:68865
Mus musculus PIP4K2B MGD MGI:1934234
Canis familiaris PIP4K2B VGNC VGNC:44571
Others PIP4K2B NCBI