USP44 - ubiquitin specific peptidase 44 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84101

About USP44

Cytogenetic location: 12q22 Genomic coordinates (GRCh38): 12:95,516,560-95,551,681 (from NCBI)

This gene has 8 transcripts (splice variants), 198 orthologues, 71 paralogues and is associated with 61 phenotypes. Biased expression in testis (RPKM 9.0), lung (RPKM 1.3) and 1 other tissue.

Summary

The protein encoded by this gene is a protease that functions as a deubiquitinating enzyme. The encoded protein is thought to help regulate the spindle assembly checkpoint by preventing early anaphase onset. This protein specifically deubiquitinates CDC20, which stabilizes the anaphase promoting complex/cyclosome. [provided by RefSeq, Dec 2016]

USP44 Products (5)

mRNA	Protein	Name
NM_001042403.3	NP_001035862.1	ubiquitin carboxyl-terminal hydrolase 44
NM_001278393.2	NP_001265322.1	ubiquitin carboxyl-terminal hydrolase 44
NM_001347936.2	NP_001334865.1	ubiquitin carboxyl-terminal hydrolase 44
NM_001347937.2	NP_001334866.1	ubiquitin carboxyl-terminal hydrolase 44
NM_032147.5	NP_115523.2	ubiquitin carboxyl-terminal hydrolase 44

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	14715245	GOA
enables cysteine-type deubiquitinase activity	IMP IMP: Inferred from mutant phenotype	17443180	GOA
enables deubiquitinase activity	IDA IDA: Inferred from direct assay	17443180	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17443180	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	31968013	GOA
involved in negative regulation of mitotic metaphase/anaphase transition	IDA IDA: Inferred from direct assay	17443180	GOA
involved in negative regulation of ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	17443180	GOA
involved in protein deubiquitination	IDA IDA: Inferred from direct assay	17443180	GOA
involved in regulatory T cell differentiation	IDA IDA: Inferred from direct assay	32644293	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in nucleus	IDA IDA: Inferred from direct assay	32644293	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20402667	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP44 Protein Structure

zf-UBP

UCH

0
200
400
600
712 a.a.

Protein Preferred Names	Protein Names
ubiquitin carboxyl-terminal hydrolase 44	deubiquitinating enzyme 44

USP44 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	USP44	Q9H0E7	CETN2	Homo sapiens	P41208	Anti Tag CoIP	33961781
Intra	USP44	Q9H0E7	CETN2	Homo sapiens	P41208	Anti Tag CoIP	28514442
Intra	USP44	Q9H0E7	CETN2	Homo sapiens	P41208	Anti Tag CoIP	19615732
Intra	USP44	Q9H0E7	FOXP3	Homo sapiens	Q9BZS1	Anti Tag CoIP	32644293

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Embryonal Carcinoma	Embryonal Neoplasm Embryonal Cancer Primary Extragonadal Embryonal Carcinoma Embryo Neoplasm Carcinoma Embryonal Cancer Embryonal Carcinoma, Embryonal Extragonadal Embryonal Carcinoma Cancer, Embryonal
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Lissencephaly	Pachygyria Broad Gyri Of Cerebrum Large Gyri Of Cerebrum Macrogyria
Strabismus	Strabismus, Susceptibility To Strabismus, Susceptibility To, 1 Strabismus 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15555	USP44 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21079	Usp44 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27596	Usp44 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	USP44	VGNC	VGNC:66887
Bos taurus	USP44	VGNC	VGNC:36731
Macaca mulatta	USP44	VGNC	VGNC:79221
Mus musculus	USP44	MGD	MGI:3045318
Canis familiaris	USP44	VGNC	VGNC:48197
Rattus norvegicus	USP44	RGD	RGD:1308216
Others	USP44	NCBI