Dgat1 - diacylglycerol O-acyltransferase 1 Gene

Also Known as ARAT; Dgat

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 84497

Summary

Enables diacylglycerol O-acyltransferase activity; diacylglycerol binding activity; and fatty acid binding activity. Involved in several processes, including Insulin secretion; positive regulation of hepatic stellate cell activation; and regulation of lipid metabolic process. Located in intracellular membrane-bounded organelle and plasma membrane. Biomarker of chronic kidney disease and nephrotic syndrome. Human ortholog(s) of this gene implicated in cardiomyopathy and congenital diarrhea 7 with exudative enteropathy. Orthologous to human DGAT1 (diacylglycerol O-acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Dgat1 Products (1)

mRNA	Protein	Name
NM_053437.2	NP_445889.2	diacylglycerol O-acyltransferase 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables acyltransferase activity	IMP IMP: Inferred from mutant phenotype	18768481	RGD
enables diacylglycerol O-acyltransferase activity	IDA IDA: Inferred from direct assay	12193544	RGD
enables diacylglycerol binding	IDA IDA: Inferred from direct assay	14596837	RGD
enables fatty acid binding	IDA IDA: Inferred from direct assay	14596837	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in glycerolipid metabolic process	IDA IDA: Inferred from direct assay	12193544	RGD
involved in insulin secretion	IMP IMP: Inferred from mutant phenotype	12193544	RGD
involved in ketone body metabolic process	IMP IMP: Inferred from mutant phenotype	23449193	RGD
involved in positive regulation of fatty acid oxidation	IMP IMP: Inferred from mutant phenotype	23449193	RGD
involved in positive regulation of hepatic stellate cell activation	IMP IMP: Inferred from mutant phenotype	18000880	RGD
involved in positive regulation of triglyceride biosynthetic process	IMP IMP: Inferred from mutant phenotype	23449193	RGD
involved in regulation of eating behavior	IMP IMP: Inferred from mutant phenotype	23449193	RGD
involved in regulation of intestinal lipid absorption	IMP IMP: Inferred from mutant phenotype	18768481	RGD
involved in regulation of vitamin A metabolic process	IMP IMP: Inferred from mutant phenotype	18000880	RGD
involved in response to human chorionic gonadotropin	IEP IEP: Inferred from expression pattern	17032584	RGD
involved in triglyceride biosynthetic process	IDA IDA: Inferred from direct assay	14596837	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
diacylglycerol O-acyltransferase 1	acyl-CoA retinol O-fatty-acyltransferase acyl-coenzyme A:diacylglycerol acyltransferase 1 diacylglycerol acyltransferase diglyceride acyltransferase retinol O-fatty-acyltransferase

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153507	DGAT1-IN-4	Inhibitor	/	Unkown
HY-N16614	Ent-Calquiquelignan E	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dgat1	NCBI	NCBI:8694