Hamp - hepcidin antimicrobial peptide Gene

Also Known as Hepc; Hamp1; Hepc1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 84506

Summary

This gene encodes hepcidin, an antimicrobial peptide and master hormonal regulator of systemic iron metabolism. The encoded preproprotein is synthesized in the hepatocytes where it undergoes proteolytic processing to generate disulfide-linked mature peptides that are secreted into the bloodstream. Mice lacking the encoded protein develop multivisceral iron overlaod, with sparing of the spleen macrophages. Certain mutations in the human ortholog of this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis. This gene is located adjacent to a related hepcidin gene on chromosome 7. [provided by RefSeq, Aug 2016]

Hamp Products (1)

mRNA Protein Name
NM_032541.2 NP_115930.1 hepcidin preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables copper ion binding IDA
IDA: Inferred from direct assay
20113314 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell surface receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
20530874 MGI
acts upstream of or within defense response to bacterium IDA
IDA: Inferred from direct assay
11113131 MGI
acts upstream of or within defense response to bacterium IMP
IMP: Inferred from mutant phenotype
23390527 MGI
acts upstream of or within defense response to fungus IDA
IDA: Inferred from direct assay
2995362 MGI
acts upstream of establishment of localization in cell IGI
IGI: Inferred from genetic interaction
21700773 MGI
acts upstream of inflammatory response IGI
IGI: Inferred from genetic interaction
20530874 MGI
involved in intracellular iron ion homeostasis IDA
IDA: Inferred from direct assay
11447267 MGI
acts upstream of iron ion transmembrane transport IGI
IGI: Inferred from genetic interaction
21700773 MGI
acts upstream of macrophage activation IMP
IMP: Inferred from mutant phenotype
22383698 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IDA
IDA: Inferred from direct assay
20113314 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
16574947 MGI
acts upstream of or within myeloid cell homeostasis IMP
IMP: Inferred from mutant phenotype
24357729 MGI
acts upstream of or within negative regulation of bone resorption IMP
IMP: Inferred from mutant phenotype
24561287 MGI
acts upstream of or within negative regulation of inflammatory response IGI
IGI: Inferred from genetic interaction
20530874 MGI
acts upstream of or within negative regulation of iron ion transmembrane transport IGI
IGI: Inferred from genetic interaction
21700773 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18539898 MGI
acts upstream of or within positive regulation of macrophage activation IMP
IMP: Inferred from mutant phenotype
22383698 MGI
acts upstream of or within positive regulation of protein catabolic process IDA
IDA: Inferred from direct assay
21700773 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
18800028 MGI
acts upstream of protein catabolic process IDA
IDA: Inferred from direct assay
21700773 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
18800028 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
11447267 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
17435114 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11113132 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hepcidin

  • hepcidin antimicrobial peptide 1

Recombinant Hamp Proteins

Cat. No. Product Name Accession Purity
HY-P700634 Hepcidin/HAMP Protein, Mouse (GST) Q9EQ21 (D59-T83) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05995 HAMP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24724 Hamp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990617 Anti-Hepcidin/HAMP Antibody (LY2787106) Inhibitor 98.23% Unkown
HY-P991881 KY1070 / Unkown
HY-P992183 AN-LP1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hamp NCBI NCBI:57817