Hamp - hepcidin antimicrobial peptide Gene

Also Known as Hepc

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84604

Summary

Predicted to enable copper ion binding activity; hormone activity; and iron ion transmembrane transporter inhibitor activity. Involved in several processes, including cellular response to X-ray; cellular response to cytokine stimulus; and cellular response to lipid. Located in apical cortex; extracellular space; and intercalated disc. Used to study anemia and hepatocellular carcinoma. Biomarker of several diseases, including anemia (multiple); end stage renal disease; extrahepatic cholestasis; iron deficiency anemia; and liver disease (multiple). Human ortholog(s) of this gene implicated in hemochromatosis; hemochromatosis type 2B; and hepatocellular carcinoma. Orthologous to human HAMP (hepcidin antimicrobial peptide). [provided by Alliance of Genome Resources, Apr 2022]

Hamp Products (1)

mRNA Protein Name
NM_053469.2 NP_445921.1 hepcidin precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in acute-phase response IEP
IEP: Inferred from expression pattern
22469696 RGD
involved in cellular response to X-ray IEP
IEP: Inferred from expression pattern
17090718 RGD
involved in cellular response to bile acid IEP
IEP: Inferred from expression pattern
19652645 RGD
involved in cellular response to interleukin-6 IEP
IEP: Inferred from expression pattern
23506423 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
23506423 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
23506423 RGD
involved in intracellular iron ion homeostasis IDA
IDA: Inferred from direct assay
14592944 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
22364558 RGD
involved in positive regulation of cell growth involved in cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
24424338 RGD
involved in response to erythropoietin IEP
IEP: Inferred from expression pattern
18306987 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
19008338 RGD
involved in response to iron ion starvation IEP
IEP: Inferred from expression pattern
21115976 RGD
involved in response to vitamin A IEP
IEP: Inferred from expression pattern
24998947 RGD
involved in response to zinc ion IEP
IEP: Inferred from expression pattern
21430246 RGD
Cellular Component GO Annotation Evidence References Source
located in apical cortex IDA
IDA: Inferred from direct assay
15684344 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
24895335 RGD
located in intercalated disc IDA
IDA: Inferred from direct assay
17363462 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hepcidin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05995 HAMP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24724 Hamp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990617 Anti-Hepcidin/HAMP Antibody (LY2787106) Inhibitor 98.23% Unkown
HY-P991881 KY1070 / Unkown
HY-P992183 AN-LP1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hamp NCBI NCBI:57817