SSH2 - slingshot protein phosphatase 2 Gene

Also Known as SSH-2; SSH-2L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 85464

About SSH2

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:29,625,938-29,930,228 (from NCBI)

This gene has 13 transcripts (splice variants), 264 orthologues and 30 paralogues. Broad expression in lymph node (RPKM 6.2), appendix (RPKM 6.0) and 24 other tissues.

Summary

This gene encodes a protein tyrosine Phosphatase that plays a key role in the regulation of actin filaments. The encoded protein dephosphorylates and activates cofilin, which promotes actin filament depolymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

SSH2 Products (4)

mRNA Protein Name
NM_001282129.2 NP_001269058.1 protein phosphatase Slingshot homolog 2 isoform 1
NM_001282130.2 NP_001269059.1 protein phosphatase Slingshot homolog 2 isoform 3
NM_001282131.2 NP_001269060.1 protein phosphatase Slingshot homolog 2 isoform 4
NM_033389.3 NP_203747.2 protein phosphatase Slingshot homolog 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables actin binding IDA
IDA: Inferred from direct assay
11832213 GOA
enables phosphoprotein phosphatase activity IDA
IDA: Inferred from direct assay
11832213 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
33961781 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
11832213 GOA
involved in protein dephosphorylation IMP
IMP: Inferred from mutant phenotype
11832213 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SSH2 Protein Structure

DEK_C

DEK_C: DEK C terminal domain (250 - 302)

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (315 - 443)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1423 a.a.
Protein Preferred Names Protein Names

protein phosphatase Slingshot homolog 2

  • SSH-like protein 2

SSH2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
SSH2 Q76I76 HECTD1 Homo sapiens Q9ULT8
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Familial Renal Oncocytoma
Melanotic Medulloblastoma

  • Medulloblastoma, Melanotic
Nephronophthisis 1

  • NPHP1

  • Nephronophthisis, Familial Juvenile

  • Nph1

  • Nephronophthisis 1, Juvenile

  • Juvenile Nephronophthisis 1

  • Familial Juvenile Nephronophthisis 1

  • Nephronophthisis, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-155847 LYP-IN-3 99.80% Unkown
HY-183573 PTPRO-IN-1 Inhibitor / Unkown
HY-RS13810 SSH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SSH2 VGNC VGNC:46832
Felis catus SSH2 VGNC VGNC:65704
Rattus norvegicus SSH2 RGD RGD:1309389
Macaca mulatta SSH2 VGNC VGNC:78018
Bos taurus SSH2 VGNC VGNC:35313
Mus musculus SSH2 MGD MGI:2679255
Others SSH2 NCBI