TRPC1 - Trpc1 transient receptor potential cation channel, subfamily C, member 1 Gene

Also Known as Trrp1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 89821

Summary

Predicted to enable several functions, including ATPase binding activity; inositol 1,4,5 trisphosphate binding activity; and store-operated Calcium Channel activity. Involved in cellular response to hypoxia. Predicted to be located in basolateral plasma membrane; membrane raft; and myofibril. Predicted to be part of cation channel complex and receptor complex. Predicted to be integral component of plasma membrane. Biomarker of type 2 diabetes mellitus. Orthologous to human TRPC1 (transient receptor potential cation channel subfamily C member 1). [provided by Alliance of Genome Resources, Apr 2022]

TRPC1 Products (4)

mRNA Protein Name
NM_001413355.1 NP_001400284.1 short transient receptor potential channel 1 isoform 1
NM_053558.3 NP_446010.2 short transient receptor potential channel 1 isoform 2
NM_001413355.1 NP_001400284.1 short transient receptor potential channel 1 isoform 1
NM_053558.3 NP_446010.2 short transient receptor potential channel 1 isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
19889962 RGD
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
31996247 RGD
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
31996247 RGD
Cellular Component GO Annotation Evidence References Source
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
14614461 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
14614461 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

short transient receptor potential channel 1

  • TRP-1

  • short transient receptor potential channel 1-like

  • transient receptor protein 1

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-30234A Clemizole hydrochloride Inhibitor 99.99% Yes
HY-30234 Clemizole Inhibitor 98.42% Yes

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101507 Zerencotrep Inhibitor 99.47% Unkown
HY-30234S Clemizole-d4 Inhibitor 99.82% Unkown
HY-138868 17-Phenyl trinor prostaglandin E2 ethyl amide Agonist / Unkown
HY-184164 JD03-02 Antagonist / Unkown
HY-RS15104 TRPC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-30234B Clemizole sulfate Inhibitor / Unkown
HY-RS17997 Trpc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24469 Trpc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens TRPC1 NCBI NCBI:7220