FIBP - FGF1 intracellular binding protein Gene

Also Known as FGFIBP; FIBP-1; TROFAS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9158

About FIBP

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,883,740-65,888,471 (from NCBI)

This gene has 13 transcripts (splice variants), 218 orthologues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 27.1), brain (RPKM 21.5) and 25 other tissues.

Summary

Acidic Fibroblast Growth Factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic Fibroblast Growth Factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

FIBP Products (2)

mRNA	Protein	Name
NM_004214.5	NP_004205.2	acidic fibroblast growth factor intracellular-binding protein isoform b
NM_198897.2	NP_942600.1	acidic fibroblast growth factor intracellular-binding protein isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables fibroblast growth factor binding	IPI IPI: Inferred from physical interaction	9806903	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	9806903	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9806903	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FIBP Protein Structure

FIBP

0
100
200
300
364 a.a.

Protein Preferred Names	Protein Names
acidic fibroblast growth factor intracellular-binding protein	aFGF intracellular-binding protein

Recombinant FIBP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72641	FIBP Protein, Human	O43427-2/NP_004205.2 (M1-D357)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Thauvin-Robinet-Faivre Syndrome	Tall Stature-Intellectual Disability-Renal Anomalies Syndrome TROFAS
Learning Disability	Learning Disabilities Learning Disorders Academic Skill Disorder Learning Disorder
Overgrowth Syndrome	Overgrowth Congenital Malformation Syndromes Involving Early Overgrowth
Coloboma, Ocular, Autosomal Dominant	Coloboma, Ocular Coloboma Of Iris, Choroid, And Retina Coi Coloboma, Uveoretinal COAD Ocular Coloboma Uveoretinal Coloboma Chronic Obstructive Airway Disease
Coloboma Of Macula	Coloboma Congenital Ocular Coloboma Microphthalmia, Isolated, With Coloboma Agenesis Of Macula Hereditary Macular Coloboma Ocular Coloboma Coloboma Of Eye Macular Coloboma Uveoretinal Coloboma
Protoplasmic Astrocytoma	Protoplasmic Astrocytic Tumor Astrocytoma Protoplasmic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04942	FIBP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19330	Fibp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25821	Fibp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FIBP	VGNC	VGNC:29006
Felis catus	FIBP	VGNC	VGNC:62271
Canis familiaris	FIBP	VGNC	VGNC:40878
Mus musculus	FIBP	MGD	MGI:1926233
Macaca mulatta	FIBP	VGNC	VGNC:72663
Rattus norvegicus	FIBP	RGD	RGD:628715
Others	FIBP	NCBI