IL32 - interleukin 32 Gene

Also Known as NK4; TAIF; TAIFa; TAIFb; TAIFc; TAIFd; IL-32beta; IL-32alpha; IL-32delta; IL-32gamma

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9235

About IL32

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,065,403-3,069,530 (from NCBI)

This gene has 35 transcripts (splice variants) and 8 orthologues. Broad expression in small intestine (RPKM 122.1), spleen (RPKM 121.0) and 22 other tissues.

Summary

This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

IL32 Products (19)

mRNA Protein Name
NM_001012631.4 NP_001012649.1 interleukin-32 isoform B
NM_001012632.3 NP_001012650.1 interleukin-32 isoform B
NM_001012633.4 NP_001012651.1 interleukin-32 isoform A
NM_001012634.4 NP_001012652.1 interleukin-32 isoform C
NM_001012635.4 NP_001012653.1 interleukin-32 isoform C
NM_001012636.2 NP_001012654.1 interleukin-32 isoform D
NM_001012718.4 NP_001012736.1 interleukin-32 isoform B
NM_001308078.4 NP_001295007.1 interleukin-32 isoform E precursor
NM_001369587.3 NP_001356516.1 interleukin-32 isoform E precursor
NM_001369588.3 NP_001356517.1 interleukin-32 isoform E precursor
NM_001369589.3 NP_001356518.1 interleukin-32 isoform B
NM_001369590.3 NP_001356519.1 interleukin-32 isoform C
NM_001369591.3 NP_001356520.1 interleukin-32 isoform C
NM_001369592.3 NP_001356521.1 interleukin-32 isoform C
NM_001369593.3 NP_001356522.1 interleukin-32 isoform F
NM_001369595.3 NP_001356524.1 interleukin-32 isoform G
NM_001369596.3 NP_001356525.1 interleukin-32 isoform B
NM_001376923.1 NP_001363852.1 interleukin-32 isoform B
NM_004221.7 NP_004212.4 interleukin-32 isoform B

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16488976 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of negative regulation of viral life cycle IDA
IDA: Inferred from direct assay
23729669 GOA
acts upstream of positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23729669 GOA
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
23729669 GOA
acts upstream of or within positive regulation of type III interferon production IDA
IDA: Inferred from direct assay
23729669 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL32 Protein Structure

IL32

IL32: Interleukin 32 (114 - 211)

  • 0
  • 100
  • 200
  • 234 a.a.
Protein Preferred Names Protein Names

interleukin-32

  • interleukin-32 eta

IL32 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IL32 P24001 RHBDD2 Homo sapiens Q6NTF9-3
Validated Y2H
32296183
Intra
IL32 P24001 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Prey Pooling
32296183
Intra
IL32 P24001 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL32 Proteins

Cat. No. Product Name Accession Purity
HY-P73884 IL-32 alpha Protein, Human (HEK293, His) P24001-4/NP_001012651 (M1-K131) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700124AF Animal-Free IL-32 alpha Protein, Human (His) P24001-4 (M1-K131) ≥ 95%, as determined by reducing SDS-PAGE.

IL32 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810960 IL-32 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P83166 IL-32 Antibody (YA2911) WB Human

Related Diseases

Diseases Alias
Microscopic Polyangiitis

  • Microscopic Polyarteritis

  • Mpa

  • Micropolyangiitis
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Granulomatosis With Polyangiitis

  • GPA

  • Wegener Granulomatosis

  • Wegener Granulomatosis, Formerly

  • Midline Granulomatosis

  • Wg, Formerly

  • Necrotizing Respiratory Granulomatosis

  • Wg

  • Wegeners Granulomatosis

  • Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis
Rheumatoid Arthritis

  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06756 IL32 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174608 Human IL32 mRNA / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992248 Anti-IL-32 Antibody / Unkown