IL32 - interleukin 32 Gene

Homo sapiens

Also known as NK4; TAIF; TAIFa; TAIFb; TAIFc; TAIFd; IL-32beta; IL-32alpha; IL-32delta; IL-32gamma

Gene ID: 9235 | Gene type: protein coding

About IL32

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,065,403-3,069,530 (from NCBI)

This gene has 35 transcripts (splice variants) and 8 orthologues. Broad expression in small intestine (RPKM 122.1), spleen (RPKM 121.0) and 22 other tissues.

Summary

This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

IL32 Products(19)

mRNA	Protein	Name
NM_001012631.4	NP_001012649.1	interleukin-32 isoform B
NM_001012632.3	NP_001012650.1	interleukin-32 isoform B
NM_001012633.4	NP_001012651.1	interleukin-32 isoform A
NM_001012634.4	NP_001012652.1	interleukin-32 isoform C
NM_001012635.4	NP_001012653.1	interleukin-32 isoform C
NM_001012636.2	NP_001012654.1	interleukin-32 isoform D
NM_001012718.4	NP_001012736.1	interleukin-32 isoform B
NM_001308078.4	NP_001295007.1	interleukin-32 isoform E precursor
NM_001369587.3	NP_001356516.1	interleukin-32 isoform E precursor
NM_001369588.3	NP_001356517.1	interleukin-32 isoform E precursor
NM_001369589.3	NP_001356518.1	interleukin-32 isoform B
NM_001369590.3	NP_001356519.1	interleukin-32 isoform C
NM_001369591.3	NP_001356520.1	interleukin-32 isoform C
NM_001369592.3	NP_001356521.1	interleukin-32 isoform C
NM_001369593.3	NP_001356522.1	interleukin-32 isoform F
NM_001369595.3	NP_001356524.1	interleukin-32 isoform G
NM_001369596.3	NP_001356525.1	interleukin-32 isoform B
NM_001376923.1	NP_001363852.1	interleukin-32 isoform B
NM_004221.7	NP_004212.4	interleukin-32 isoform B

IL32 Protein Structure

IL32

0
100
200
234 a.a.

Protein Preferred Names

Protein Names

interleukin-32

interleukin-32 eta

Recombinant IL32 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73884	IL-32 Protein, Human (HEK293, His)	P24001-4/NP_001012651 (M1-K131)	≥95%
HY-P700124AF	Animal-Free IL-32 alpha Protein, Human (His)	P24001-4 (M1-K131)	≥95%

Related Diseases

Diseases

Alias

Microscopic Polyangiitis

Microscopic Polyarteritis	Mpa
Micropolyangiitis

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Granulomatosis With Polyangiitis

GPA	Wegener Granulomatosis
Wegener Granulomatosis, Formerly	Midline Granulomatosis
Wg, Formerly	Necrotizing Respiratory Granulomatosis
Wg	Wegeners Granulomatosis
Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon