TNFSF8 - TNF superfamily member 8 Gene
Also Known as CD153; CD30L; CD30LG; TNLG3A
Species: Homo sapiens
About TNFSF8
This gene has 3 transcripts (splice variants) and 118 orthologues. Biased expression in lymph node (RPKM 9.3), appendix (RPKM 6.6) and 11 other tissues.
Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of Other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
TNFSF8 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001244.4 | NP_001235.1 | tumor necrosis factor ligand superfamily member 8 isoform 1 |
| NM_001252290.1 | NP_001239219.1 | tumor necrosis factor ligand superfamily member 8 isoform 2 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
TNFSF8 Protein Structure
TNF: TNF(Tumour Necrosis Factor) family (113 - 229)
- 0
- 100
- 200
- 234 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
tumor necrosis factor ligand superfamily member 8 |
|
TNFSF8 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
TNFSF8 | P32971 | CXCL9 | Homo sapiens | Q07325 | 32296183 |
Recombinant TNFSF8 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P76224 | CD30 Ligand/TNFSF8 Protein, Human (HEK293) | P32971 (Q63-D234) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P76225 | CD30 Ligand/TNFSF8 Protein, Human (HEK293, hFc) | P32971 (Q63-D234) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P78405 | CD30 Ligand/TNFSF8 Protein, Human (HEK293, mFc) | P32971 (Q63-D234) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P700036AF | Animal-Free CD30 Ligand/TNFSF8 Protein, Human (His) | P32971 (Q63-D234) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P700434 | CD30 Ligand/TNFSF8 Protein, Human (HEK293, N-His) | P32971 (Q63-D234) | ≥ 90%, as determined by reducing SDS-PAGE. |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Anaplastic Large Cell Lymphoma |
|
|
| Lymphoma, Hodgkin, Classic |
|
|
| Lymphoma |
|
|
| Spastic Diplegia |
|
|
| Lymphoma, Non-Hodgkin, Familial |
|
|
| Leukemia, Acute Lymphoblastic |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS14829 | TNFSF8 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-174512 | Human TNFSF8 mRNA | / | Unkown | |
| HY-RS18100 | Tnfsf8 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS24574 | Tnfsf8 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | TNFSF8 | MGD | MGI:88328 |
| Bos taurus | TNFSF8 | VGNC | VGNC:36177 |
| Rattus norvegicus | TNFSF8 | RGD | RGD:1590403 |
| Canis familiaris | TNFSF8 | VGNC | VGNC:47673 |
| Felis catus | TNFSF8 | VGNC | VGNC:102999 |
| Others | TNFSF8 | NCBI |
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