GPRIN2 - G protein regulated inducer of neurite outgrowth 2 Gene
Also Known as GRIN2; KIAA0514
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 9721
About GPRIN2
Cytogenetic location: 10q11.22
Genomic coordinates (GRCh38): 10:46,541,736-46,557,596 (from NCBI)
This gene has 2 transcripts (splice variants), 174 orthologues and 1 paralogue. Biased expression in lung (RPKM 5.6), skin (RPKM 4.9) and 12 other tissues.
Summary
Predicted to be involved in neuron projection development. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
GPRIN2 Products (28)
| mRNA | Protein | Name |
|---|---|---|
| NM_001385275.1 | NP_001372204.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 1 |
| NM_001385276.1 | NP_001372205.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 1 |
| NM_001385277.1 | NP_001372206.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 1 |
| NM_001385278.1 | NP_001372207.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 1 |
| NM_001385279.1 | NP_001372208.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 1 |
| NM_001385280.1 | NP_001372209.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 1 |
| NM_001385281.1 | NP_001372210.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 1 |
| NM_001385282.1 | NP_001372211.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 1 |
| NM_001385283.1 | NP_001372212.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 1 |
| NM_001385287.1 | NP_001372216.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 2 |
| NM_001385289.1 | NP_001372218.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 2 |
| NM_001385291.1 | NP_001372220.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 2 |
| NM_001385293.1 | NP_001372222.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 2 |
| NM_001385294.1 | NP_001372223.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 2 |
| NM_001385295.1 | NP_001372224.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 2 |
| NM_001385296.1 | NP_001372225.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 2 |
| NM_001385297.1 | NP_001372226.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 2 |
| NM_001385298.1 | NP_001372227.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 2 |
| NM_001385299.1 | NP_001372228.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 2 |
| NM_001385300.1 | NP_001372229.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 2 |
| NM_001385301.1 | NP_001372230.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 2 |
| NM_001394739.1 | NP_001381668.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 1 |
| NM_001394740.1 | NP_001381669.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 1 |
| NM_001394741.1 | NP_001381670.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 1 |
| NM_001394742.1 | NP_001381671.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 2 |
| NM_001394743.1 | NP_001381672.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 2 |
| NM_001394744.1 | NP_001381673.1 | G protein-regulated inducer of neurite outgrowth 2 isoform 2 |
| NM_014696.5 | NP_055511.2 | G protein-regulated inducer of neurite outgrowth 2 isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
15778465 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
GPRIN2 Protein Structure
GRIN_C
GRIN_C: G protein-regulated inducer of neurite outgrowth C-terminus (346 - 456)
- 0
- 100
- 200
- 300
- 400
- 458 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
G protein-regulated inducer of neurite outgrowth 2 |
|
GPRIN2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
GPRIN2 | O60269 | HTR4 | Homo sapiens | Q13639 | 28298427 | |
|
Intra
|
GPRIN2 | O60269 | HTR4 | Homo sapiens | Q13639 | 28298427 |
Cross: Cross-species interaction
Intra: Intraspecies interaction
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Spinocerebellar Ataxia 23 |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(1)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS05755 | GPRIN2 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | GPRIN2 | VGNC | VGNC:62696 |
| Macaca mulatta | GPRIN2 | VGNC | VGNC:72992 |
| Mus musculus | GPRIN2 | MGD | MGI:2444560 |
| Bos taurus | GPRIN2 | VGNC | VGNC:29610 |
| Rattus norvegicus | GPRIN2 | RGD | RGD:1308922 |
| Canis familiaris | GPRIN2 | VGNC | VGNC:41453 |
| Others | GPRIN2 | NCBI |
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