NCAPD2 - non-SMC condensin I complex subunit D2 Gene

Also Known as CNAP1; CAP-D2; MCPH21; hCAP-D2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9918

About NCAPD2

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,494,102-6,531,955 (from NCBI)

This gene has 13 transcripts (splice variants), 197 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in lymph node (RPKM 20.3), bone marrow (RPKM 14.5) and 24 other tissues.

Summary

Enables histone binding activity. Involved in mitotic chromosome condensation. Located in condensed chromosome; cytosol; and nucleoplasm. Part of condensin complex. Colocalizes with cytoplasm and nuclear chromosome. Implicated in primary autosomal recessive microcephaly. [provided by Alliance of Genome Resources, Apr 2022]

NCAPD2 Products (1)

mRNA	Protein	Name
NM_014865.4	NP_055680.3	condensin complex subunit 1

NCAPD2 Protein Structure

Cnd1_N

Cnd1

0
300
600
900
1200
1401 a.a.

Protein Preferred Names	Protein Names
condensin complex subunit 1	XCAP-D2 homolog

NCAPD2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NCAPD2	Q15021	NCAPH	Homo sapiens	Q15003	Anti Bait CoIP	17268547

Cross: Cross-species interaction Intra: Intraspecies interaction

NCAPD2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86979	NCAPD2 Antibody (YA6672)	WB, ICC/IF, IHC-P	Human

Related Diseases

Diseases	Alias
Microcephaly 21, Primary, Autosomal Recessive	MCPH21
Spastic Monoplegia	Monoplegic Infantile Cerebral Palsy Spastic Monoplegic Cerebral Palsy Infantile Monoplegic Cerebral Palsy Cerebral Palsy Spastic Monoplegic Spastic Monoplegia Cerebral Palsy
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Microcephaly 19, Primary, Autosomal Recessive	MCPH19 Primary Autosomal Recessive Microcephaly 19 Microcephaly, Type 19, Primary, Autosomal Recessive
Osteogenesis Imperfecta, Type Ix	Osteogenesis Imperfecta Type 9 Osteogenesis Imperfecta Type Ix OI9 Oi Type Ix Osteogenesis Imperfecta Sillence Type Ii/Iii Without Abnormality Of Type I Collagen Oi, Type Ix Oi 9 Osteogenesis Imperfecta 9 Oi-Ix
Primary Microcephaly	True Microcephaly Microcephaly, Primary
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09066	NCAPD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NCAPD2	VGNC	VGNC:43639
Rattus norvegicus	NCAPD2	RGD	RGD:1562596
Macaca mulatta	NCAPD2	VGNC	VGNC:75015
Bos taurus	NCAPD2	VGNC	VGNC:31901
Mus musculus	NCAPD2	MGD	MGI:1915548
Felis catus	NCAPD2	VGNC	VGNC:82373
Others	NCAPD2	NCBI