GLP-1R modulator C5

製品番号: HY-141840 純度: 99.81%: Data Sheet SDS COA 取扱説明書
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GLP-1R modulator C5 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC₅₀ 1.59 ± 0.53 μM).

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GLP-1R modulator C5 構造式

CAS 番号 : 421578-93-0

容量	価格（税別）	在庫状況	数量

>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 110	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 110	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$100	在庫あり	Estimated Time of Arrival: December 31
10 mg	$160	在庫あり	Estimated Time of Arrival: December 31
25 mg	$350	在庫あり	Estimated Time of Arrival: December 31
50 mg	$550	在庫あり	Estimated Time of Arrival: December 31
100 mg	$950	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

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Based on 0 publication(s) in Google Scholar

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製品説明

GLP-1R modulator C5 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC₅₀ 1.59 ± 0.53 μM).

分子量

371.43

分子式

C₂₄H₂₁NO₃

CAS 番号

421578-93-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CC=C1)CC2(C(N(C3=CC=CC=C32)CCC4=CC=CC=C4)=O)O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 50 mg/mL (134.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6923 mL	13.4615 mL	26.9230 mL
5 mM	0.5385 mL	2.6923 mL	5.3846 mL
10 mM	0.2692 mL	1.3461 mL	2.6923 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.81%

Select Batch:

データシート (272 KB) SDS (251 KB)

COA (255 KB) HNMR (126 KB) LCMS (100 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Wang J, et al. Allosteric Modulators Enhancing GLP-1 Binding to GLP-1R via a Transmembrane Site. ACS Chem Biol. 2021 Nov 19;16(11):2444-2452. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6923 mL	13.4615 mL	26.9230 mL	67.3074 mL
	5 mM	0.5385 mL	2.6923 mL	5.3846 mL	13.4615 mL
	10 mM	0.2692 mL	1.3461 mL	2.6923 mL	6.7307 mL
	15 mM	0.1795 mL	0.8974 mL	1.7949 mL	4.4872 mL
	20 mM	0.1346 mL	0.6731 mL	1.3461 mL	3.3654 mL
	25 mM	0.1077 mL	0.5385 mL	1.0769 mL	2.6923 mL
	30 mM	0.0897 mL	0.4487 mL	0.8974 mL	2.2436 mL
	40 mM	0.0673 mL	0.3365 mL	0.6731 mL	1.6827 mL
	50 mM	0.0538 mL	0.2692 mL	0.5385 mL	1.3461 mL
	60 mM	0.0449 mL	0.2244 mL	0.4487 mL	1.1218 mL
	80 mM	0.0337 mL	0.1683 mL	0.3365 mL	0.8413 mL
	100 mM	0.0269 mL	0.1346 mL	0.2692 mL	0.6731 mL