Glucocerebrosidase-IN-1 hydrochloride

Cat. No.: HY-147976A Purity: 99.16%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Glucocerebrosidase-IN-1 (compound 11a) hydrochloride is a potent and selective GCase (glucocerebrosidase) inhibitor, with an IC₅₀ of 29.3 μM and a K_i of 18.5 μM. Glucocerebrosidase-IN-1 hydrochloride can be used for the research of Gaucher disease (GD) and Parkinson’s disease (PD).

For research use only. We do not sell to patients.

Glucocerebrosidase-IN-1 hydrochloride Chemical Structure

CAS No. : 2279945-77-4

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 Customer Validation

Other Forms of Glucocerebrosidase-IN-1 hydrochloride:

Glucocerebrosidase-IN-1 In-stock

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

281.82

Formula

C₁₃H₂₈ClNO₃

CAS No.

2279945-77-4

Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1[C@@H](CCCCCCCC)NC[C@@H](O)[C@H]1O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 12.5 mg/mL (44.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5484 mL	17.7418 mL	35.4836 mL
5 mM	0.7097 mL	3.5484 mL	7.0967 mL
10 mM	0.3548 mL	1.7742 mL	3.5484 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.16%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (244 KB) HNMR (256 KB) LCMS (321 KB)

Handling Instructions (2659 KB)

References

[1]. Clemente F, et al. Glucocerebrosidase (GCase) activity modulation by 2-alkyl trihydroxypiperidines: Inhibition and pharmacological chaperoning. Bioorg Chem. 2020 May;98:103740. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5484 mL	17.7418 mL	35.4836 mL	88.7091 mL
	5 mM	0.7097 mL	3.5484 mL	7.0967 mL	17.7418 mL
	10 mM	0.3548 mL	1.7742 mL	3.5484 mL	8.8709 mL
	15 mM	0.2366 mL	1.1828 mL	2.3656 mL	5.9139 mL
	20 mM	0.1774 mL	0.8871 mL	1.7742 mL	4.4355 mL
	25 mM	0.1419 mL	0.7097 mL	1.4193 mL	3.5484 mL
	30 mM	0.1183 mL	0.5914 mL	1.1828 mL	2.9570 mL
	40 mM	0.0887 mL	0.4435 mL	0.8871 mL	2.2177 mL