Glucocerebrosidase-IN-1 hydrochloride

Art. -Nr.: HY-147976A Reinheit: 99.16%: Data Sheet
COA

SDS
Handling Instructions
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Glucocerebrosidase-IN-1 (compound 11a) hydrochloride is a potent and selective GCase (glucocerebrosidase) inhibitor, with an IC₅₀ of 29.3 μM and a K_i of 18.5 μM. Glucocerebrosidase-IN-1 hydrochloride can be used for the research of Gaucher disease (GD) and Parkinson’s disease (PD).

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Glucocerebrosidase-IN-1 hydrochloride Chemische Struktur

CAS. Nr. : 2279945-77-4

Größe	Verfügbarkeit	Menge
1 mg	Auf Lager	Estimated Time of Arrival: December 31
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Angebot einholen
100 mg	Angebot einholen

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Other Forms of Glucocerebrosidase-IN-1 hydrochloride:

Glucocerebrosidase-IN-1 In-stock

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität
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Beschreibung

Molekulargewicht

281.82

Formel

C₁₃H₂₈ClNO₃

CAS. Nr.

2279945-77-4

Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1[C@@H](CCCCCCCC)NC[C@@H](O)[C@H]1O.[H]Cl

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 12.5 mg/mL (44.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5484 mL	17.7418 mL	35.4836 mL
5 mM	0.7097 mL	3.5484 mL	7.0967 mL
10 mM	0.3548 mL	1.7742 mL	3.5484 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 99.16%

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Data Sheet (268 KB) SDS (251 KB)

COA (244 KB) HNMR (256 KB) LCMS (321 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Clemente F, et al. Glucocerebrosidase (GCase) activity modulation by 2-alkyl trihydroxypiperidines: Inhibition and pharmacological chaperoning. Bioorg Chem. 2020 May;98:103740. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5484 mL	17.7418 mL	35.4836 mL	88.7091 mL
	5 mM	0.7097 mL	3.5484 mL	7.0967 mL	17.7418 mL
	10 mM	0.3548 mL	1.7742 mL	3.5484 mL	8.8709 mL
	15 mM	0.2366 mL	1.1828 mL	2.3656 mL	5.9139 mL
	20 mM	0.1774 mL	0.8871 mL	1.7742 mL	4.4355 mL
	25 mM	0.1419 mL	0.7097 mL	1.4193 mL	3.5484 mL
	30 mM	0.1183 mL	0.5914 mL	1.1828 mL	2.9570 mL
	40 mM	0.0887 mL	0.4435 mL	0.8871 mL	2.2177 mL