GP3269
GP3269 is a selective and orally active human adenosine kinase (AK) inhibitor with an IC50 of 11 nM against human adenosine kinase. GP3269 increases adenosine levels at epileptic foci, activates A1 receptors on excitatory neurons, and exhibits anticonvulsant activity in rats. GP3269 does not induce hemodynamic effects including changes in blood pressure or heart rate in rats. GP3269 can be used for epilepsy-related research.
For research use only. We do not sell to patients.
- CAS No.: 186393-42-0
- Formula: C23H21FN4O3
- Molecular Weight:420.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| IMR-32 | IC50 |
134 nM
Compound: 4
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Inhibition of adenosine phosphorylation in confluent IMR-32 (human neuroblastoma) cells.
Inhibition of adenosine phosphorylation in confluent IMR-32 (human neuroblastoma) cells.
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[PMID: 11405650] |
GP3269 (20 minutes at 37 °C) potently inhibits purified pig heart adenosine kinase with an IC50 of 11 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 186393-42-0
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Molecular Weight 420.44
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Formula C23H21FN4O3
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SMILES
O[C@H]([C@@H]([C@H](O1)C)O)[C@]1([H])N2C3=NC=NC(NC4=CC=C(C=C4)F)=C3C(C5=CC=CC=C5)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GP3269 Related Classifications
HY-19259 Related Classifications
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