GS-443902 trisodium (Synonyms: GS-441524 triphosphate trisodium; Remdesivir metabolite trisodium)

Name: GS-443902 trisodium
Brand: MedChemExpress
SKU: HY-126303C
Rating: 5.0 (13 reviews)

Cat. No.: HY-126303C Pureza: 99.94%: Ficha de datos
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GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC₅₀s of 1.1 μM, 5 μM for RSV RdRp and HCV RdRp, respectively. GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734).

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GS-443902 trisodium Estructura química

No. CAS : 1355050-21-3

Tamaño	Stock	Cantidad
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Revisión del cliente

Based on 13 publication(s) in Google Scholar

Other Forms of GS-443902 trisodium:

GS-443902 Obtener un presupuesto

13 Publications Citing Use of MCE GS-443902 trisodium

•Curr Res Pharmacol Drug Discov. 2021:2:100045. [Abstract]

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Referencias
Revisión del cliente

Descripciòn

IC₅₀ & Target

IC50: 1.1 μM (RSV RdRp) and 5 μM (HCV RdRp)^[1]^[2]

In Vitro

In a continuous 72 h incubation of 1 μM Remdesivir (GS-5734), the GS-443902 trisodium (GS-441524 triphosphate trisodium; Remdesivir metabolite trisodium) level is measured at 2, 24, 48 and 72 h, and reaches a C_max of 300, 110, and 90 pmol/million cells in macrophages, HMVEC, and HeLa cells lines respectively^[1].
GS-443902 trisodium (compound 8a) is a triphosphates (TP) derivative^[2].
GS-443902 trisodium (NTP; 0.01, 0.1, 1, 10, 100 μM) inhibits RSV RdRp-catalysed RNA synthesis by incorporating into the nascent viral RNA transcript and causing its premature termination. GS-5734 selectively inhibits EBOV replication by targeting its RdRp and inhibiting viral RNA synthesis following efficient intracellular conversion to GS-443902 sodium^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Remdesivir (GS-5734; 10 mg kg; i.v.) rapidly distributes into peripheral blood mononuclear cells (PBMCs), and efficient conversion to GS-443902 trisodium (Remdesivir metabolite trisodium; NTP) is apparent within 2 h of dose administration in rhesus monkeys. In PBMCs, GS-443902 trisodium represents the predominant metabolite and is persistent with a t_1/2 of 14 h and levels required for >50% virus inhibition for 24 hours^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

597.15

Fòrmula

C₁₂H₁₃N₅Na₃O₁₃P₃

No. CAS

1355050-21-3

Appearance

Solid

Color

White to light yellow

SMILES

O=P(OP(O)(O[Na])=O)(O[Na])OP(OC[C@@H](O1)[C@@H](O)[C@@H](O)[C@]1(C#N)C2=CC=C3N2N=CN=C3N)(O[Na])=O

Envío

Shipping with dry ice.

Almacenamiento

-80°C, protect from light, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvente y solubilidad

In Vitro:

H₂O : 33.33 mg/mL (55.82 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6746 mL	8.3731 mL	16.7462 mL
5 mM	0.3349 mL	1.6746 mL	3.3492 mL
10 mM	0.1675 mL	0.8373 mL	1.6746 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (83.73 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureza y Documentación

Purity: 99.94%

Select Batch:

Ficha de datos (278 KB) SDS (252 KB)

COA (253 KB) HNMR (379 KB) RP-HPLC (204 KB) LCMS (98 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Siegel D, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. Med Chem. 2017 Mar 9;60(5):1648-1661. [Content Brief]

[2]. Warren TK, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016 Mar 17;531(7594):381-5. [Content Brief]

[3]. Cho A, et al. Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2705-7. [Content Brief]

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.6746 mL	8.3731 mL	16.7462 mL	41.8655 mL
	5 mM	0.3349 mL	1.6746 mL	3.3492 mL	8.3731 mL
	10 mM	0.1675 mL	0.8373 mL	1.6746 mL	4.1866 mL
	15 mM	0.1116 mL	0.5582 mL	1.1164 mL	2.7910 mL
	20 mM	0.0837 mL	0.4187 mL	0.8373 mL	2.0933 mL
	25 mM	0.0670 mL	0.3349 mL	0.6698 mL	1.6746 mL
	30 mM	0.0558 mL	0.2791 mL	0.5582 mL	1.3955 mL
	40 mM	0.0419 mL	0.2093 mL	0.4187 mL	1.0466 mL
	50 mM	0.0335 mL	0.1675 mL	0.3349 mL	0.8373 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

GS-443902 trisodium Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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GS-443902 trisodium (Synonyms: GS-441524 triphosphate trisodium; Remdesivir metabolite trisodium)

Revisión del cliente

Other Forms of GS-443902 trisodium:

GS-443902 trisodium Related Antibodies

13 Publications Citing Use of MCE GS-443902 trisodium

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas DNA/RNA Synthesis:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

GS-443902 trisodium Related Antibodies

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

GS-443902 trisodium Related Classifications

Keywords:

Productos vistos recientemente:

Revisión del cliente

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SAFETY DATA SHEET (SDS)

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