HBV-IN-30
HBV-IN-30 (ex44), a flavone derivative, is a potent covalently closed circular DNA (cccDNA) inhibitor. cccDNA serves as the template for viral RNA transcription and subsequent viral DNA generation. HBV-IN-30 has the potential for the research of HBV infection.
For research use only. We do not sell to patients.
- CAS No.: 2413192-92-2
- Formula: C22H18BrClO6
- Molecular Weight:493.73
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
HBV-IN-30 (ex44; 24 h) inhibits HBeAg levels and cell viability with an IC50 value of 0.57 μM in HepDES19 cells. HepDES19 is the cell line that produces cccDNA[1].
HBV-IN-30 (5 days) decreases cccDNA levels in HepDES19 cells in a dose-dependent manner[1].
HBV-IN-30 (9 days; primary human hepatocyte (PHH)) has anti-HBV effect and inhibits HBeAg with an IC50 value of 0.04 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2413192-92-2
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Molecular Weight 493.73
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Formula C22H18BrClO6
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SMILES
ClC1=C2C(C(C=C(C3=CC(Br)=C(C=C3)OCCO[C@@H]4C[C@@H](C4)C(O)=O)O2)=O)=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HBV-IN-30 Related Classifications
HY-148781 Related Classifications
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