HC103A 

HC103A is an Antibacterial agent and a DosS/DosT histidine sensor kinase inhibitor, with an IC₅₀ of 0.5 μM against DosS and ~5 μM against DosT of *Mycobacterium tuberculosis*. HC103A inhibits the autophosphorylation of DosS/DosT. HC103A suppresses hypoxia-induced triacylglycerol synthesis and the viability of Mtb. HC103A can be used in the research of tuberculosis^[1][2].

HC103A (0.1-100 μM; 6 d) potently and selectively inhibits DosR-dependent GFP fluorescence in Mycobacterium tuberculosis CDC1551(hspX′::GFP) with an EC₅₀ of 2.7 μM without affecting bacterial growth^[1].
HC103A (40 μM) reduces triacylglycerol accumulation by 56% in Mycobacterium tuberculosis CDC1551, disrupting a key persistence-associated lipid metabolism pathway^[1].
HC103A (0-60 μM; 1 h) directly inhibits autophosphorylation of purified Mycobacterium tuberculosis DosS (IC₅₀ 0.5 μM) and DosT (IC₅₀ ~5 μM) sensor kinases without altering their heme redox status^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

338.38

C₁₈H₁₄N₂O₃S

312595-37-2

O=C(NC1=CC=CC(=C1)C(=O)NC=2C=CC=C(O)C2)C=3SC=CC3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zheng H, et al. Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence. Nat Chem Biol. 2017;13(2):218-225.

  [2]. Zheng H, et al. Inhibiting Mycobacterium tuberculosis DosRST Signaling by Targeting Response Regulator DNA Binding and Sensor Kinase Heme. ACS Chem Biol. 2020 Jan 17;15(1):52-62.