312595-37-2
Chemical Structure
HC103A
- CAS No.: 312595-37-2
- Formula:C18H14N2O3S
- Molecular Weight:338.38
IUPAC Name: N-(3-((3-hydroxyphenyl)carbamoyl)phenyl)thiophene-2-carboxamide
InChIKey: RFBZYRMLQURAPP-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(=C1)C(=O)NC=2C=CC=C(O)C2)C=3SC=CC3
Biological Activity: HC103A is an Antibacterial agent and a DosS/DosT histidine sensor kinase inhibitor, with an IC50 of 0.5 μM against DosS and ~5 μM against DosT of *Mycobacterium tuberculosis*. HC103A inhibits the autophosphorylation of DosS/DosT. HC103A suppresses hypoxia-induced triacylglycerol synthesis and the viability of Mtb. HC103A can be used in the research of tuberculosis[1][2].
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HC103A | HC103A is an Antibacterial agent and a DosS/DosT histidine sensor kinase inhibitor, with an IC50 of 0.5 μM against DosS and ~5 μM against DosT of *Mycobacterium tuberculosis*. HC103A inhibits the autophosphorylation of DosS/DosT. HC103A suppresses hypoxia-induced triacylglycerol synthesis and the viability of Mtb. HC103A can be used in the research of tuberculosis. | |||||||||||||||||||||
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- [1]. Zheng H, et al. Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence. Nat Chem Biol. 2017;13(2):218-225. [Content Brief]
- [2]. Zheng H, et al. Inhibiting Mycobacterium tuberculosis DosRST Signaling by Targeting Response Regulator DNA Binding and Sensor Kinase Heme. ACS Chem Biol. 2020 Jan 17;15(1):52-62. [Content Brief]
Keywords
