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Cat. No.: HY-D3282

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CCF1

CCF1 is a carbon-rhodol-based turn-on fluorescent copper sensor with high selectivity for Cu⁺ over other biologically relevant metal ions. CCF1 detects changes in labile copper pools in living cells upon copper supplementation and/or depletion. CCF1 identifies elevations in labile copper pools in Atp7a^-/^- fibroblast cell models. CCF1 can be used for the research of Menkes disease.

For research use only. We do not sell to patients.

CAS No.: 2158208-42-3
Formula: C₄₀H₅₁F₃N₂O₂S₄
Molecular Weight:777.10

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CCF1 Chemical Structure

CAS No.: 2158208-42-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Bioz

Biological Activity

Description

In Vitro

CCF1 is a fluorescent sensor with Cu⁺ selectivity in aqueous buffer at physiological pH, which produces a 5-fold fluorescence turn-on response with an apparent Cu⁺-binding K_d of 0.20 pM^[1].
CCF1 (2 μM; 15 min) detects increased and decreased levels of labile copper pools in live HEK 293T cells, with enhanced fluorescence under copper supplementation conditions and reduced fluorescence under copper depletion conditions^[1].
CCF1 (2 μM; 10 min) detects elevated levels of labile copper pools in live Atp7a^-/- MEFs relative to wild-type MEF controls^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2158208-42-3
Molecular Weight 777.10
Formula C₄₀H₅₁F₃N₂O₂S₄
SMILES

CCSCCSCCN(CC1=CC=C(C(C(F)(F)F)=C1)C2=C3C=CC(C=C3C(C)(C4=C2C=CC(N5CCOCC5)=C4)C)=O)CCSCCSCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jia S, et al. Tuning the Color Palette of Fluorescent Copper Sensors through Systematic Heteroatom Substitution at Rhodol Cores. ACS Chem Biol. 2018;13(7):1844-1852. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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