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Cat. No.: HY-P11149

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Human Defensin-5 (1-9)

Human Defensin-5 (1-9) is an orally active antimicrobial peptide. Human Defensin-5 (1-9) can inhibit metabolic disorders induced by Western-style diet (WSD) or Western-style diet with fructose (WSDF). Human Defensin-5 (1-9) enhances intestinal barrier function by upregulating the gene expression of ileal tight junction protein and mucins. Human Defensin-5 (1-9) can be used for the study of obesity and related metabolic diseases.

For research use only. We do not sell to patients.

Formula: C₄₀H₆₈N₁₆O₁₂S₂
Molecular Weight:1029.20

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Human Defensin-5 (1-9) Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vivo

Human Defensin-5 (1-9) (1.2 mg/kg, i.g., once daily, 6 weeks) reduces liver fat content and the number of hepatic lipid droplets in male C57BL/6J mice fed a Western-style diet with fructose (WSDF)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male C57BL/6J mice fed a Western-style diet with fructose (WSDF)^[1]
Dosage:

1.2 mg/kg
Administration:

i.g., once daily, 6 weeks
Result:

Achieved liver fat reduction rates with statistical significance and hepatic lipid droplet reduction rates.
Showed a significant decrease in mesenteric fat cell area and a trend of reducing fat cell size.
Reduced blood glucose levels at 30 and 60 min post-glucose challenge and decreased glucose AUC.
Upregulated ileal ZO-1, Muc1 gene expression, showed a trend of upregulating Muc2 and reduced Lac/Man ratio.
Induced ileal Defa5, Lyz1, Reg3γand Wnt signaling molecules (Wnt3, Wnt5a, Wnt9a, Tcf1) gene expression.

Chemical Information

Molecular Weight 1029.20
Formula C₄₀H₆₈N₁₆O₁₂S₂
Sequence

Ala-Thr-Cys-Tyr-Cys-Arg-Thr-Gly-Arg-NH2
Sequence Shortening

ATCYCRTGR-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (261 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Filipe Rosa L, et al. Human α-Defensin 51-9 and Human β-Defensin 2 Improve Metabolic Parameters and Gut Barrier Function in Mice Fed a Western-Style Diet. Int J Mol Sci. 2023 Sep 9;24(18):13878. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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