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United States

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Cat. No.: HY-158097

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IAV-IN-2

IAV-IN-2 (Compound MC-22) inhibits for Influenza A Virus (IAV) through blocking the entry of IAV into host cell via clathrin-mediated endocytosis (CME).

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화학식: C₂₂H₂₅N₃O₅
분자량:411.45

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

IAV-IN-2 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IAV-IN-2 (Compound MC-22) inhibits for Influenza A Virus (IAV) through blocking the entry of IAV into host cell via clathrin-mediated endocytosis (CME)^[1].

In Vitro

IAV-IN-2 (0.01-10 µM) inhibits IAV A/X‐31 (H3N2) (with IC₅₀ of 4.08 μM), A/WSN/33 (H1N1), A/Udorn/72 (H3N2) and A/NYMC (H3N2) with 97%–100% inhibitory potency^[1].
IAV-IN-2 (1-1000 μM) exhibits cytotoxicity in cell A549 with CC₅₀ of 33.9 μM^[1].
IAV-IN-2 (10 μM) causes endosomal maturation defect, which disrupts the step-wise priming of the viral core during its endosomal trafficking, disabling the virus to uncoat its capsid and release its genome into the cell^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

A549
Concentration:

1-1000 μM
Incubation Time:

24 h
Result:

Exhibited cytotoxicity in A549.

Chemical Information

분자량 411.45
화학식 C₂₂H₂₅N₃O₅
SMILES

O=C(C1=CC=C(/N=N/N2CCOCC2)C=C1)/C=C/C3=CC(OC)=C(OC)C(OC)=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Thottasseri AA, et al., Morpholinodiazenyl chalcone blocks influenza A virus capsid uncoating by perturbing the clathrin-mediated vesicular trafficking pathway. Arch Pharm (Weinheim). 2024 Mar 15:e2300670. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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