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Cat. No.: HY-169572

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IGF-1R inhibitor-5

IGF-1R inhibitor-5 (compound 19) is a potent inhibitor of IGF-1R, with the IC₅₀ of 6 μM. IGF-1R inhibitor-5 has the potential for the research of cancer.

For research use only. We do not sell to patients.

CAS No.: 331652-38-1
Formula: C₁₄H₇Cl₂NO₃S
Molecular Weight:340.18

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

IGF-1R inhibitor-5 Chemical Structure

CAS No.: 331652-38-1

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
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Biological Activity

Description

IGF-1R inhibitor-5 (compound 19) is a potent inhibitor of IGF-1R, with the IC₅₀ of 6 μM. IGF-1R inhibitor-5 has the potential for the research of cancer^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	21.5 μM Compound: 40b(E)	Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay	[PMID: 20178321]

Chemical Information

CAS No. 331652-38-1
Molecular Weight 340.18
Formula C₁₄H₇Cl₂NO₃S
SMILES

O=C1S/C(C(N1)=O)=C/C2=CC=C(C3=C(Cl)C(Cl)=CC=C3)O2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. East China University of Science and Technology, et al. Use of 5-substituted-2, 4-thiazolidinediones in preparation of medicaments for modulating insulin-like growth factor 1 receptor. World Intellectual Property Organization, WO2011063602 A1 2011-06-03

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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IGF-1R inhibitor-5

High-Throughput Bioactive Compound Library

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

IGF-1R inhibitor-5 Related Classifications

HY-169572 Related Classifications