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DBR1 - debranching RNA lariats 1 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51163

About DBR1

Cytogenetic location: 3q22.3 Genomic coordinates (GRCh38): 3:138,160,988-138,174,921 (from NCBI)

This gene has 10 transcripts (splice variants), 207 orthologues and is associated with 1 phenotype. Ubiquitous expression in stomach (RPKM 5.7), bone marrow (RPKM 5.2) and 25 other tissues.

Summary

The protein encoded by this gene is an RNA lariat debranching enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. The encoded protein specifically targets the bonds at the branch point of excised lariat intron RNA, converting them to linear molecules that are then degraded. This protein may also be involved in retroviral replication. [provided by RefSeq, Nov 2011]

DBR1 Products (1)

mRNA	Protein	Name
NM_016216.4	NP_057300.2	lariat debranching enzyme

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA lariat debranching enzyme activity	IMP IMP: Inferred from mutant phenotype	10982890	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in RNA fragment catabolic process	IMP IMP: Inferred from mutant phenotype	37656279	GOA
involved in RNA splicing, via transesterification reactions	IMP IMP: Inferred from mutant phenotype	10982890	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	10982890	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DBR1 Protein Structure

Metallophos

DBR1

0
100
200
300
400
500
544 a.a.

Protein Preferred Names	Protein Names
lariat debranching enzyme	RNA lariat debranching enzyme

Related Diseases

Diseases	Alias
Encephalitis, Acute, Infection -Induced 11	IIAE11 Encephalitis, Acute, Infection -Induced, Susceptibility To, 11 Encephalitis, Acute, Infection -Induced, 11
Viral Encephalitis	Epidemic Encephalitis Encephalitis Viral Encephalitis, Arbovirus Arbovirus Encephalitis Postviral Encephalitis Nos Equine Encephalitis Tick-Borne Encephalitis Viral Encephalitis Transmitted By Tick Mosquito-Borne Encephalitis Acute Haemorrhagic Encephalitis Acute Idiopathic Encephalitis Chronic Viral Encephalitis Endemic Encephalitis Subacute Viral Encephalitis Viral Haemorrhagic Encephalitis Viral Nonepidemic Encephalitis Nonepidemic Encephalitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156744	DBr-1	Degrader	98.87%	Unkown
HY-RS03553	DBR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DBR1	VGNC	VGNC:61350
Macaca mulatta	DBR1	VGNC	VGNC:71626
Rattus norvegicus	DBR1	RGD	RGD:1598038
Bos taurus	DBR1	VGNC	VGNC:27895
Canis familiaris	DBR1	VGNC	VGNC:39786
Mus musculus	DBR1	MGD	MGI:1931520
Others	DBR1	NCBI