Influenza virus-IN-5

ADC Targets in Oncology

2026-04-10

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	>25 μM Compound: 5f	Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 E572K mutant expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staini Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 E572K mutant expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staini	[PMID: 31753804]
HeLa	EC₅₀	0.88 μM Compound: 5f	Inhibition of influenza H3N2 A/X-31 hemagglutinin 3 expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staining based microscopic Inhibition of influenza H3N2 A/X-31 hemagglutinin 3 expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staining based microscopic	[PMID: 31753804]
HeLa	EC₅₀	≥21 μM Compound: 5f	Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 D1122N expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.6 by giemsa staining bas Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 D1122N expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.6 by giemsa staining bas	[PMID: 31753804]
MDCK	CC₅₀	1.5 μM Compound: 5f	Cytotoxicity against MDCK cells assessed as reduction in cell viability after 4 days by MTS assay Cytotoxicity against MDCK cells assessed as reduction in cell viability after 4 days by MTS assay	[PMID: 31753804]
MDCK	EC₅₀	0.0012 μM Compound: 5f	Antiviral activity against Influenza A virus H3N2 A/HK/7/87 infected in MDCK cells assessed as reduction in virus induced cytopathic effect after 4 days by microscopy based method Antiviral activity against Influenza A virus H3N2 A/HK/7/87 infected in MDCK cells assessed as reduction in virus induced cytopathic effect after 4 days by microscopy based method	[PMID: 31753804]
MDCK	EC₅₀	0.00077 μM Compound: 5f	Antiviral activity against IInfluenza A virus H3N2 A/HK/7/87 infected in MDCK cells after 4 days by MTS assay Antiviral activity against IInfluenza A virus H3N2 A/HK/7/87 infected in MDCK cells after 4 days by MTS assay	[PMID: 31753804]
MDCK	EC₅₀	0.77 nM Compound: 5f	Antiviral activity against IInfluenza A virus H3N2 A/HK/7/87 infected in MDCK cells after 4 days by MTS assay Antiviral activity against IInfluenza A virus H3N2 A/HK/7/87 infected in MDCK cells after 4 days by MTS assay	[PMID: 31753804]

Cell Line

Type

Value

Description

References

HeLa

EC₅₀

>25 μM

Compound: 5f

Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 E572K mutant expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staini

[PMID: 31753804]

HeLa

EC₅₀

0.88 μM

Compound: 5f

Inhibition of influenza H3N2 A/X-31 hemagglutinin 3 expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staining based microscopic

[PMID: 31753804]

HeLa

EC₅₀

≥21 μM

Compound: 5f

Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 D1122N expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.6 by giemsa staining bas

[PMID: 31753804]

MDCK

CC₅₀

1.5 μM

Compound: 5f

Cytotoxicity against MDCK cells assessed as reduction in cell viability after 4 days by MTS assay

[PMID: 31753804]

MDCK

EC₅₀

0.0012 μM

Compound: 5f

Antiviral activity against Influenza A virus H3N2 A/HK/7/87 infected in MDCK cells assessed as reduction in virus induced cytopathic effect after 4 days by microscopy based method

[PMID: 31753804]

MDCK

EC₅₀

0.00077 μM

Compound: 5f

Antiviral activity against IInfluenza A virus H3N2 A/HK/7/87 infected in MDCK cells after 4 days by MTS assay

[PMID: 31753804]

MDCK

EC₅₀

0.77 nM

Compound: 5f

Antiviral activity against IInfluenza A virus H3N2 A/HK/7/87 infected in MDCK cells after 4 days by MTS assay

[PMID: 31753804]

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Influenza virus-IN-5

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Influenza virus-IN-5 Related Classifications

HY-146147 Related Classifications