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Cat. No.: HY-186310

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ISRACT-02

ISRACT-02 is a eIF2B modulator. The K_d values of ISRACT-02 for eIF2B^WT and eIF2B^Δ-latch are 174 nM and 385 nM, respectively. Depending on the conformation of its amide bond (trans or cis), ISRACT-02 binds to and stabilizes the inactive conformation (I-state) or active conformation (A-state) of eIF2B, respectively. ISRACT-02 can be used in studies related to leukodystrophy, Alzheimer's disease, traumatic brain injury, and Down syndrome.

For research use only. We do not sell to patients.

Formula: C₂₉H₃₁Cl₂N₃O₄
Molecular Weight:556.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ISRACT-02 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Calculators
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Biological Activity

Description

In Vitro

ISRACT-02 (at a molar ratio of 15:1 to eIF2B^Δ-latch decamer; 30 min) is an A-state biased modulator that stabilizes either the inactive I-state or active A-state of the eIF2B^Δ-latch decamer depending on its amide bond isomerization state^[1].
FAM-ISRACT-02 (2.5 nM; 30 min) exhibits higher binding affinity to the active state A eIF2B^WT decamer than to the inactive state I eIF2B^Δ-latch decamer, with corresponding K_d values of 174 nM and 385 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 556.48
Formula C₂₉H₃₁Cl₂N₃O₄
SMILES

O=C(N[C@H]1CC[C@@H](CC1)N(C(CCOC2=CC=C(C=C2)Cl)=O)CC3=CC=NC=C3)COC4=CC=C(C=C4)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dalwadi U, et al. Allosteric disordering of eIF2B regulates the integrated stress response. Nature chemical biology. 2026 Jun 29.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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