Tle4 - transducin-like enhancer of split 4 Gene

Also Known as Bce1; Grg4; Bce-1; grg-4; ESTM13; ESTM14; 5730411M05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21888

Summary

Enables DNA-binding transcription factor binding activity; chromatin binding activity; and transcription corepressor activity. Involved in negative regulation of transcription, DNA-templated. Acts upstream of or within Wnt signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; embryo mesenchyme; genitourinary system; and peripheral nervous system ganglion. Orthologous to human TLE4 (TLE family member 4, transcriptional corepressor). [provided by Alliance of Genome Resources, Apr 2022]

Tle4 Products (4)

mRNA Protein Name
NM_001302947.2 NP_001289876.1 transducin-like enhancer protein 4 isoform 1
NM_001302950.2 NP_001289879.1 transducin-like enhancer protein 4 isoform 3
NM_001302951.2 NP_001289880.1 transducin-like enhancer protein 4 isoform 4
NM_011600.4 NP_035730.2 transducin-like enhancer protein 4 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
21317240 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
16002402 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12050133 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
12050133 MGI
enables transcription corepressor activity IGI
IGI: Inferred from genetic interaction
15729346 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Wnt signaling pathway IDA
IDA: Inferred from direct assay
15105370 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12050133 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
21317240 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16002402 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
23371388 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
17060451 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transducin-like enhancer protein 4

  • B lymphocyte gene 1

  • groucho-related protein 4

  • transducin-like enhancer of split 4, homolog of Drosophila E(spl)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14566 TLE4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21444 Tle4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27962 Tle4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tle4 NCBI NCBI:7091