LHX9 - LIM homeobox 9 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56956

About LHX9

Cytogenetic location: 1q31.3 Genomic coordinates (GRCh38): 1:197,912,464-197,935,478 (from NCBI)

This gene has 8 transcripts (splice variants), 204 orthologues and 20 paralogues. Biased expression in ovary (RPKM 2.6), testis (RPKM 0.9) and 1 other tissue.

Summary

This gene encodes a member of the LIM homeobox gene family of developmentally expressed transcription factors. The encoded protein contains a homeodomain and two cysteine-rich zinc-binding LIM domains involved in protein-protein interactions. The protein is highly similar to a mouse protein that causes gonadal agenesis when inactivated, suggesting a role in gonadal development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

LHX9 Products (4)

mRNA Protein Name
NM_001014434.2 NP_001014434.1 LIM/homeobox protein Lhx9 isoform 2
NM_001370213.1 NP_001357142.1 LIM/homeobox protein Lhx9 isoform 3
NM_001410927.1 NP_001397856.1 LIM/homeobox protein Lhx9 isoform 4
NM_020204.3 NP_064589.2 LIM/homeobox protein Lhx9 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LHX9 Protein Structure

LIM

LIM: LIM domain (71 - 128)

LIM

LIM: LIM domain (133 - 188)

Homeobox

Homeobox: Homeobox domain (268 - 324)

  • 0
  • 100
  • 200
  • 300
  • 397 a.a.
Protein Preferred Names Protein Names

LIM/homeobox protein Lhx9

  • LIM homeobox protein 9

LHX9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LHX9 Q9NQ69 KHK Homo sapiens P50053
Y2H Array
25416956
Intra
LHX9 Q9NQ69 KHK Homo sapiens P50053
Y2H Prey Pooling
25416956
Intra
LHX9 Q9NQ69 CWF19L2 Homo sapiens Q2TBE0
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Gonadal Agenesis
46,Xy Sex Reversal

  • Swyer Syndrome

  • Pure Gonadal Dysgenesis 46,Xy

  • Gonadal Dysgenesis, Xy Female Type

  • Gonadal Dysgenesis, 46,Xy

  • 46,Xy Cgd

  • 46,Xy Complete Gonadal Dysgenesis

  • 46,Xy Pure Gonadal Dysgenesis

  • 46 Xy Gonadal Dysgenesis

  • 46, Xy Cgd

  • 46, Xy Complete Gonadal Dysgenesis

  • 46, Xy Pure Gonadal Dysgenesis

  • Xy Pure Gonadal Dysgenesis

  • Female With 46,Xy Karyotype

  • Xy Females
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07638 LHX9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20766 Lhx9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27280 Lhx9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LHX9 MGD MGI:1316721
Canis familiaris LHX9 VGNC VGNC:42669
Rattus norvegicus LHX9 RGD RGD:727956
Macaca mulatta LHX9 VGNC VGNC:74044
Bos taurus LHX9 VGNC VGNC:30878
Felis catus LHX9 VGNC VGNC:63226
Others LHX9 NCBI