Agap2 - ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 Gene

Also Known as Pike; Centg1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 65218

Summary

Enables protein kinase activator activity and protein kinase binding activity. Involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of neuron apoptotic process; and positive regulation of phosphatidylinositol 3-kinase signaling. Located in nucleus. Human ortholog(s) of this gene implicated in prostate Cancer. Orthologous to human AGAP2 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 2). [provided by Alliance of Genome Resources, Apr 2022]

Agap2 Products (1)

mRNA	Protein	Name
NM_023026.2	NP_075415.2	arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	21847098	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	14528310	RGD
enables protein kinase activator activity	IDA IDA: Inferred from direct assay	11136977	RGD
enables protein kinase binding	IDA IDA: Inferred from direct assay	11136977	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	21847098	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to glycine	IDA IDA: Inferred from direct assay	21847098	RGD
involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	18469807	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	14528310	RGD
involved in phosphatidylinositol metabolic process	IMP IMP: Inferred from mutant phenotype	21847098	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	14528310	RGD
involved in positive regulation of protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	21847098	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in dendrite	IDA IDA: Inferred from direct assay	21847098	RGD
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	21847098	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2	AGAP-2 centaurin, gamma 1 cnt-g1 nuclear GTPase PIKE phosphatidylinositol 3-kinase enhancer

Agap2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Agap2	Q8CGU4	UNC5B	Homo sapiens	Q8IZJ1	Y2H	18469807
Cross	Agap2	Q8CGU4	UNC5B	Homo sapiens	Q8IZJ1	Anti Bait CoIP	18469807
Cross	Agap2	Q8CGU4	UNC5B	Homo sapiens	Q8IZJ1	Anti Tag CoIP	18469807
Intra	Agap2	Q8CGU4	Gria2	Rattus norvegicus	P19491	Anti Bait CoIP	21847098
Intra	Agap2	Q8CGU4	Grip1	Rattus norvegicus	P97879	Anti Bait CoIP	21847098

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00438	AGAP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Agap2	NCBI	NCBI:116986