Birc3 - baculoviral IAP repeat-containing 3 Gene

Also Known as IAP1; Birc2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 78971

About Birc3

Primary_assembly 8: 5,000,845-5,015,802 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 205 orthologues, 8 paralogues and is associated with 13 phenotypes. Biased expression in Spleen (RPKM 146.7), Thymus (RPKM 76.) and 8 other tissues.

Summary

Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein Ligase activity. Involved in spermatogenesis. Located in membrane raft. Part of protein-containing complex. Orthologous to human BIRC3 (baculoviral IAP repeat containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Birc3 Products (1)

mRNA Protein Name
NM_023987.3 NP_076477.3 baculoviral IAP repeat-containing protein 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
12786973 RGD
Biological Process GO Annotation Evidence References Source
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
16343737 RGD
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
12786973 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Birc3 Protein Structure

BIR

BIR: smart00238 (63 - 132)

BIR

BIR: cd00022 (205 - 271)

BIR

BIR: smart00238 (289 - 357)

UBA_BIRC2_3

UBA_BIRC2_3: cd14394 (411 - 460)

DD

DD: cl14633 (475 - 563)

RING-HC_BIRC2_3_7

RING-HC_BIRC2_3_7: cd16713 (581 - 637)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 638 a.a.
Protein Preferred Names Protein Names

baculoviral IAP repeat-containing protein 3

  • inhibitor of apoptosis protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-50685 A 410099.1 Inhibitor 99.30% Unkown
HY-180948 PZ-11 Inducer / Unkown
HY-182002 Apoptosis inducer 61 / Unkown
HY-RS01508 Birc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01510 BIRC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01511 Birc3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01512 Birc3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Birc3 NCBI NCBI:330