Nicoxamat
Based on 1 Customer Validation
Nicoxamat (N-Hydroxynicotinamide) is a HCV inhibitor as well as a selective HDAC6 inhibitor. Nicoxamat is applicable to research related to hepatitis C virus (HCV) infection.
For research use only. We do not sell to patients.
- Purity: 99.05%
- CAS No.: 5657-61-4
- Formula: C6H6N2O2
- Molecular Weight:138.13
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HDAC6 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
450 μM
Compound: II
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Cytotoxicity against human HuH7 cells transfected with luc/neo plasmid assessed as cell viability after 72 hrs by MTT method
Cytotoxicity against human HuH7 cells transfected with luc/neo plasmid assessed as cell viability after 72 hrs by MTT method
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[PMID: 25937017] |
Nicoxamat (compound IIa) inhibits the proliferation of HCV full-length genomic replicons in Huh7 luc/neo cells, with an EC50 of 25 μM, a CC50 of 450 μM, and a selectivity index of 18[1].
Nicoxamat (20-100 μM) induces concentration-dependent hyperacetylation of α-tubulin in Huh7-luc/neo cells[1].
Nicoxamat (100 μM; 72 h) does not induce significant histone H3 acetylation in Huh7-luc/neo cells, indicating its selectivity for class I HDACs[1].
Nicoxamat (0-100 μM) exhibits concentration-dependent inhibition of HCV replicon and HDAC6 inhibitory activity in Huh7-luc/neo cells, with its HCV inhibitory activity being stronger than HDAC6 inhibitory activity at low concentrations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Huh7-luc/neo cells
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Concentration:100 μM
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Incubation Time:72 h
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Result:Did not cause a significant increase in acetylated histone H3 levels at 100 μM after 72 hours of incubation.
Chemical Information
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CAS No. 5657-61-4
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Appearance Solid
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Molecular Weight 138.13
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Formula C6H6N2O2
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Color White to off-white
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SMILES
O=C(NO)C=1C=NC=CC1
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Synonyms
N-Hydroxynicotinamide
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (180.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.2396 mL | 36.1978 mL | 72.3956 mL | 180.9889 mL |
| 5 mM | 1.4479 mL | 7.2396 mL | 14.4791 mL | 36.1978 mL | |
| 10 mM | 0.7240 mL | 3.6198 mL | 7.2396 mL | 18.0989 mL | |
| 15 mM | 0.4826 mL | 2.4132 mL | 4.8264 mL | 12.0659 mL | |
| 20 mM | 0.3620 mL | 1.8099 mL | 3.6198 mL | 9.0494 mL | |
| 25 mM | 0.2896 mL | 1.4479 mL | 2.8958 mL | 7.2396 mL | |
| 30 mM | 0.2413 mL | 1.2066 mL | 2.4132 mL | 6.0330 mL | |
| 40 mM | 0.1810 mL | 0.9049 mL | 1.8099 mL | 4.5247 mL | |
| 50 mM | 0.1448 mL | 0.7240 mL | 1.4479 mL | 3.6198 mL | |
| 60 mM | 0.1207 mL | 0.6033 mL | 1.2066 mL | 3.0165 mL | |
| 80 mM | 0.0905 mL | 0.4525 mL | 0.9049 mL | 2.2624 mL | |
| 100 mM | 0.0724 mL | 0.3620 mL | 0.7240 mL | 1.8099 mL |
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