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Cat. No.: HY-181853

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NOTA-SP2A-PSMAL

NOTA-SP₂A-PSMAL is a ligand targeting prostate-specific membrane antigen (PSMA), which competitively binds to PSMA with high binding affinity and an IC₅₀ value of 0.26 nM. ¹⁸F-labeled NOTA-SP₂A-PSMAL can be used as a PET tracer for positron emission tomography imaging of prostate cancer. NOTA-SP₂A-PSMAL can be used for the synthesis and research of radionuclide conjugates (RDCs).

For research use only. We do not sell to patients.

Formula: C₅₅H₇₉N₁₁O₂₅S₂
Molecular Weight:1358.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NOTA-SP2A-PSMAL Chemical Structure

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Use of MCE Products

One-Stop Platform：From Independent R&D to Pilot-Scale Production

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Radionuclide-Drug Conjugates (RDCs) Isoforms :

In Vitro

NOTA-SP₂A-PSMAL exhibits a binding energy of -10.2 K_cal/mol and forms equivalent hydrogen bonds with human PSMA protein compared to NOTA-PSMA-BCH, indicating comparable binding stability^[1].
NOTA-SP₂A-PSMAL (10^-12 to 10^-5 M; 60 min) competitively binds to PSMA in 22Rv1 cells with high binding affinity (IC₅₀ = 0.26 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

Molecular Weight 1358.40
Formula C₅₅H₇₉N₁₁O₂₅S₂
SMILES

OC(CC[C@H](C(O)=O)NC(NC(C(O)=O)CCCCNC(C(CC1=CC=C(C=CC=C2)C2=C1)NC([C@H]3CC[C@@H](CNC([C@@H](CC(O)=O)NC([C@H](CS(=O)(O)=O)NC([C@@H](CS(=O)(O)=O)NC(CN4CCN(CC(O)=O)CCN(CC(O)=O)CC4)=O)=O)=O)=O)CC3)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang Y, et al. Design, Synthesis, and Preclinical Evaluation of a Novel [¹⁸F]AlF-Labeling Positron Emission Tomography Tracer Targeting Prostate-Specific Membrane Antigen. J Med Chem. 2026;69(4):4888-4899. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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