Cysteine-activated hydrogen sulfide (H2S) donors

  • J Am Chem Soc. 2011 Jan 12;133(1):15-7. doi: 10.1021/ja1085723.
Yu Zhao  1 ,  Hua Wang ,  Ming Xian
Affiliations
  • 1. Department of Chemistry, Washington State University, Pullman, Washington 99164, USA.
PMID: 21142018 DOI: 10.1021/ja1085723
Abstract

H(2)S, the newly discovered gasotransmitter, plays important roles in biological systems. However, the research on H(2)S has been hindered by the lack of controllable H(2)S donors that could mimic the slow and continuous H(2)S generation process in vivo. Herein we report a series of cysteine-activated H(2)S donors. Structural modifications of these molecules can regulate the rates of H(2)S generation. These compounds can be useful tools in H(2)S research.

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