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Cat. No.: HY-190191

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QC-65

QC-65 is a HO-1/HO-2 inhibitor with IC₅₀ = 4.0 μM for HO-1 and IC₅₀ = 11.3 μM for HO-2. QC-65 can be used in research on HO-1-mediated related diseases, such as cancer.

For research use only. We do not sell to patients.

CAS No.: 741628-94-4
Formula: C₁₃H₁₄N₂O
Molecular Weight:214.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

QC-65 Chemical Structure

CAS No.: 741628-94-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
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Description

QC-65 is a HO-1/HO-2 inhibitor with IC₅₀ = 4.0 μM for HO-1 and IC₅₀ = 11.3 μM for HO-2. QC-65 can be used in research on HO-1-mediated related diseases, such as cancer^[1].

IC₅₀ & Target

^[1]

HO-1

4.0 μM (IC₅₀)

HO-2

11.3 μM (IC₅₀)

All Heme Oxygenase (HO) Isoforms :

HO-1
HO-2

In Vitro

QC-65 (1-100 μM; 60 min at 37 °C) inhibits rat spleen HO-1 and rat brain HO-2 with IC₅₀ values of 4.0 μM and 11.3 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 741628-94-4
Molecular Weight 214.26
Formula C₁₃H₁₄N₂O
SMILES

O=C(CCC1=CC=CC=C1)CN2C=CN=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Fallica AN, et al. Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent Antiproliferative Activity. Journal of medicinal chemistry. 2021 Sep 23;64(18):13373-13393. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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QC-65

All Heme Oxygenase (HO) Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

QC-65 Related Classifications

HY-190191 Related Classifications

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