1. MAPK/ERK Pathway
  2. JNK
  3. JNK-IN-8 (GMP)

JNK-IN-8 (GMP)  (Synonyms: JNK Inhibitor XVI (GMP))

Cat. No.: HY-13319G
Handling Instructions

JNK-IN-8 (JNK Inhibitor XVI) (GMP) is JNK-IN-8 (HY-13319) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. JNK-IN-8 is a potent JNK inhibitor with IC50s of 4.7 nM, 18.7 nM, and 1 nM for JNK1, JNK2, and JNK3, respectively.

For research use only. We do not sell to patients.

JNK-IN-8 (GMP) Chemical Structure

JNK-IN-8 (GMP) Chemical Structure

CAS No. : 1410880-22-6

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Top Publications Citing Use of Products

    JNK-IN-8 (GMP) purchased from MCE. Usage Cited in: J Exp Clin Cancer Res. 2018 May 4;37(1):99.  [Abstract]

    A co-inhibitor of JNK and integrin β obviously decreases phosphorylation levels of JNK and c-JUN and expression of LOXL2 as compared with JNK inhibitor alone or integrin β1 alone.

    JNK-IN-8 (GMP) purchased from MCE. Usage Cited in: J Biol Chem. 2014 Oct 17;289(42):28753-64.  [Abstract]

    Effect of the JNK inhibitor (JNK IN 8) on the induction of MKP-1 and MKP-2. RAW264.7 cells are first pretreated with vehicle (DMSO), 3 μM JNK IN 8, 10 μM of U0126, or a combination of both JNK IN 8 and U0126, for 30 min, and then stimulated with LPS for 60 min. Representative images are shown in the panels.

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    Description

    JNK-IN-8 (JNK Inhibitor XVI) (GMP) is JNK-IN-8 (HY-13319) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. JNK-IN-8 is a potent JNK inhibitor with IC50s of 4.7 nM, 18.7 nM, and 1 nM for JNK1, JNK2, and JNK3, respectively[1].

    IC50 & Target

    IC50: 4.7/18.7/1 nM (JNK1/2/3)[1]

    In Vitro

    JNK-IN-8 (GMP) (10 μM) reduces WNT3A-mediated neuronal differentiation[1].
    JNK-IN-8 (GMP) (2 μM, 7 days) enhances the self-renewal of human hematopoietic stem cells (HSCs) through the downregulation of C-JUN phosphorylation[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    507.59

    Formula

    C29H29N7O2

    CAS No.
    SMILES

    CC1=CC(NC(C2=CC=CC(NC(/C=C/CN(C)C)=O)=C2)=O)=CC=C1NC3=NC=CC(C4=CN=CC=C4)=N3

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    Purity & Documentation
    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    JNK-IN-8 (GMP)
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