Cdkn1b - cyclin-dependent kinase inhibitor 1B Gene

Also Known as p27; Kip1; p27Kip1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12576

Summary

Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in several processes, including G1/S transition of mitotic cell cycle; heart development; and negative regulation of cardiac muscle tissue regeneration. Acts upstream of or within several processes, including negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of epithelial cell proliferation involved in prostate gland development; and positive regulation of microtubule polymerization. Located in cytosol and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; heart and pericardium; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia; breast cancer; multiple endocrine neoplasia type 4; and myelodysplastic syndrome. Orthologous to human CDKN1B (cyclin dependent kinase inhibitor 1B). [provided by Alliance of Genome Resources, Apr 2022]

Cdkn1b Products (1)

mRNA Protein Name
NM_009875.4 NP_034005.2 cyclin-dependent kinase inhibitor 1B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cyclin binding IDA
IDA: Inferred from direct assay
24380855 MGI
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
IDA: Inferred from direct assay
8033213 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8033213 MGI
Biological Process GO Annotation Evidence References Source
involved in G1/S transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
8534916 MGI
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
25535395 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
16014817 MGI
acts upstream of or within cellular response to antibiotic IDA
IDA: Inferred from direct assay
19056892 MGI
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
19056892 MGI
acts upstream of epithelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
16014817 MGI
acts upstream of epithelial cell proliferation involved in prostate gland development IMP
IMP: Inferred from mutant phenotype
16014817 MGI
involved in heart development IMP
IMP: Inferred from mutant phenotype
24380855 MGI
acts upstream of or within inner ear development IMP
IMP: Inferred from mutant phenotype
10079221 MGI
involved in negative regulation of cardiac muscle tissue regeneration IMP
IMP: Inferred from mutant phenotype
24380855 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
11751454 MGI
acts upstream of or within negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12130539 MGI
acts upstream of or within negative regulation of epithelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
16014817 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
10079221 MGI
acts upstream of or within negative regulation of epithelial cell proliferation involved in prostate gland development IMP
IMP: Inferred from mutant phenotype
16014817 MGI
acts upstream of or within placenta development IGI
IGI: Inferred from genetic interaction
9784491 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12759355 MGI
acts upstream of or within positive regulation of microtubule polymerization IGI
IGI: Inferred from genetic interaction
15652749 MGI
acts upstream of or within potassium ion transport IGI
IGI: Inferred from genetic interaction
16393152 MGI
involved in regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
24380855 MGI
acts upstream of or within regulation of cell migration IDA
IDA: Inferred from direct assay
15652749 MGI
acts upstream of or within regulation of exit from mitosis IGI
IGI: Inferred from genetic interaction
9784491 MGI
acts upstream of or within regulation of lens fiber cell differentiation IGI
IGI: Inferred from genetic interaction
9784491 MGI
acts upstream of or within regulation of mitotic cell cycle IDA
IDA: Inferred from direct assay
8033213 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
10079221 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15652749 MGI
located in cytosol IDA
IDA: Inferred from direct assay
15964824 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10827137 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cyclin-dependent kinase inhibitor 1B

  • cyclin-dependent kinase inhibitor p27

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-161989 DZ-837 Degrader 96.04% Unkown
HY-RS19053 Cdkn1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02412 CDKN1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25543 Cdkn1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdkn1b NCBI NCBI:1027