CDKN1B - cyclin dependent kinase inhibitor 1B Gene

Also Known as KIP1; MEN4; CDKN4; MEN1B; P27KIP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1027

About CDKN1B

Cytogenetic location: 12p13.1 Genomic coordinates (GRCh38): 12:12,717,368-12,722,369 (from NCBI)

This gene has 9 transcripts (splice variants), 223 orthologues, 2 paralogues and is associated with 90 phenotypes. Ubiquitous expression in fat (RPKM 40.2), ovary (RPKM 35.6) and 25 other tissues.

Summary

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK Inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]

CDKN1B Products (1)

mRNA	Protein	Name
NM_004064.5	NP_004055.1	cyclin-dependent kinase inhibitor 1B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cyclin binding	IPI IPI: Inferred from physical interaction	15024385	GOA
enables cyclin-dependent protein kinase activating kinase regulator activity	EXP EXP: Inferred from Experiment	8684460	GOA
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA IDA: Inferred from direct assay	8033212	GOA
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	8684460	GOA
enables molecular function inhibitor activity	IMP IMP: Inferred from mutant phenotype	11790096	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8684460	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	15024385	GOA
enables protein kinase inhibitor activity	IMP IMP: Inferred from mutant phenotype	8684460	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	19838216	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	8684460	GOA
enables ubiquitin ligase activator activity	EXP EXP: Inferred from Experiment	16209941	GOA
enables ubiquitin protein ligase binding	EXP EXP: Inferred from Experiment	16209941	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in autophagic cell death	IDA IDA: Inferred from direct assay	12698196	GOA
acts upstream of or within cellular response to lithium ion	IDA IDA: Inferred from direct assay	19056892	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	19170105	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	10208428	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19838216	GOA
involved in negative regulation of cyclin-dependent protein kinase activity	IMP IMP: Inferred from mutant phenotype	8684460	GOA
involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	28666995	GOA
involved in negative regulation of kinase activity	IDA IDA: Inferred from direct assay	19170105	GOA
involved in negative regulation of phosphorylation	IDA IDA: Inferred from direct assay	10208428	GOA
involved in negative regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	19088079	GOA
involved in nuclear export	IMP IMP: Inferred from mutant phenotype	12529437	GOA
acts upstream of or within positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	19056892	GOA
involved in regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	10208428	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	12093740	GOA
involved in regulation of cell cycle G1/S phase transition	IMP IMP: Inferred from mutant phenotype	8033212	GOA
involved in regulation of cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	8033212	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Cul4A-RING E3 ubiquitin ligase complex	IDA IDA: Inferred from direct assay	21628527	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12093740	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11800646	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDKN1B Protein Structure

CDI

0
100
198 a.a.

Protein Preferred Names	Protein Names
cyclin-dependent kinase inhibitor 1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)

CDKN1B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDKN1B	P46527	CDK5	Homo sapiens	Q00535	Anti Tag CoIP	34591612
Intra	CDKN1B	P46527	CDK5	Homo sapiens	Q00535	SPR	15890360
Intra	CDKN1B	P46527	CDK5	Homo sapiens	Q00535	Anti Tag CoIP	33961781
Intra	CDKN1B	P46527	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	CDKN1B	P46527	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	32296183
Intra	CDKN1B	P46527	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	CDKN1B	P46527	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	25910212
Intra	CDKN1B	P46527	BANP	Homo sapiens	Q8N9N5-2	Y2H Bait-Prey Pool	25910212
Intra	CDKN1B	P46527	BANP	Homo sapiens	Q8N9N5-2	Y2H Array	25910212
Intra	CDKN1B	P46527	CDK4	Homo sapiens	P11802	Anti Tag CoIP	34591612
Intra	CDKN1B	P46527	CDK4	Homo sapiens	P11802	Anti Bait CoIP	16326706
Intra	CDKN1B	P46527	CDK4	Homo sapiens	P11802	Anti Bait CoIP	9106657
Intra	CDKN1B	P46527	CDK4	Homo sapiens	P11802	Anti Tag CoIP	33961781
Intra	CDKN1B	P46527	CDK4	Homo sapiens	P11802	Anti Bait CoIP	17053782
Intra	CDKN1B	P46527	TRAF2	Homo sapiens	Q12933	Y2H Array	25910212
Intra	CDKN1B	P46527	TRAF2	Homo sapiens	Q12933	Y2H Bait-Prey Pool	25910212
Intra	CDKN1B	P46527	TRAF2	Homo sapiens	Q12933	Y2H Pooling	16189514
Intra	CDKN1B	P46527	TRAF2	Homo sapiens	Q12933	Validated Y2H	25910212
Intra	CDKN1B	P46527	MCM7	Homo sapiens	P33993	Pull Down	16289477
Intra	CDKN1B	P46527	KPNA3	Homo sapiens	O00505	Pull Down	15057270
Intra	CDKN1B	P46527	KPNA3	Homo sapiens	O00505	Biochemical	15057270
Intra	CDKN1B	P46527	CCND1	Homo sapiens	P24385	Anti Tag CoIP	34591612
Intra	CDKN1B	P46527	CCND1	Homo sapiens	P24385	Anti Bait CoIP	17254966
Intra	CDKN1B	P46527	CCND1	Homo sapiens	P24385	Anti Tag CoIP	9106657
Intra	CDKN1B	P46527	CCND3	Homo sapiens	P30281	Anti Tag CoIP	34591612
Intra	CDKN1B	P46527	CCND3	Homo sapiens	P30281	Anti Tag CoIP	33961781
Intra	CDKN1B	P46527	CCNE2	Homo sapiens	O96020	Anti Tag CoIP	34591612
Intra	CDKN1B	P46527	CCNE2	Homo sapiens	O96020	Anti Tag CoIP	33961781
Intra	CDKN1B	P46527	CCNE2	Homo sapiens	O96020	Y2H	9840943
Intra	CDKN1B	P46527	CCNA1	Homo sapiens	P78396	Y2H Pooling	18692475
Intra	CDKN1B	P46527	CCNA1	Homo sapiens	P78396	Anti Tag CoIP	33961781
Intra	CDKN1B	P46527	CCNA1	Homo sapiens	P78396	Lumier	32814053
Intra	CDKN1B	P46527	CCNA1	Homo sapiens	P78396	Lumier	29997244
Intra	CDKN1B	P46527	CCNA1	Homo sapiens	P78396	BRET	29997244
Intra	CDKN1B	P46527	CDK2	Homo sapiens	P24941	SPR	15890360
Intra	CDKN1B	P46527	CDK2	Homo sapiens	P24941	SPR	17254966
Intra	CDKN1B	P46527	CDK2	Homo sapiens	P24941	Anti Bait CoIP	16326706
Intra	CDKN1B	P46527	CDK2	Homo sapiens	P24941	Footprinting	15890360
Intra	CDKN1B	P46527	CDK1	Homo sapiens	P06493	Anti Tag CoIP	34591612
Intra	CDKN1B	P46527	CDK1	Homo sapiens	P06493	Anti Tag CoIP	33961781
Intra	CDKN1B	P46527	STMN1	Homo sapiens	P16949	Anti Tag CoIP	15652749
Intra	CDKN1B	P46527	STMN1	Homo sapiens	P16949	Anti Bait CoIP	21423803
Intra	CDKN1B	P46527	RHOA	Homo sapiens	P61586	Anti Bait CoIP	19470470
Intra	CDKN1B	P46527	SKP2	Homo sapiens	Q13309	ITC	16209941
Intra	CDKN1B	P46527	SKP2	Homo sapiens	Q13309	X-Ray Diffraction	16209941
Intra	CDKN1B	P46527	SKP2	Homo sapiens	Q13309	Pull Down	22632967
Intra	CDKN1B	P46527	CCNA2	Homo sapiens	P20248	SPR	15890360
Intra	CDKN1B	P46527	CCNA2	Homo sapiens	P20248	SPR	17254966
Intra	CDKN1B	P46527	CCNA2	Homo sapiens	P20248	NMR	15890360
Intra	CDKN1B	P46527	CCNA2	Homo sapiens	P20248	Footprinting	15890360
Intra	CDKN1B	P46527	CCNA2	Homo sapiens	P20248	Anti Tag CoIP	34591612
Intra	CDKN1B	P46527	CCNB1	Homo sapiens	P14635	Anti Tag CoIP	34591612
Intra	CDKN1B	P46527	CCNB1	Homo sapiens	P14635	Pull Down	8756624
Intra	CDKN1B	P46527	CCNB1	Homo sapiens	P14635	Anti Tag CoIP	33961781
Intra	CDKN1B	P46527	CCNE1	Homo sapiens	P24864	Anti Tag CoIP	34591612
Intra	CDKN1B	P46527	CCNE1	Homo sapiens	P24864	Anti Bait CoIP	17254967
Intra	CDKN1B	P46527	CCNE1	Homo sapiens	P24864	Anti Tag CoIP	33961781
Intra	CDKN1B	P46527	KPNA5	Homo sapiens	O15131	Biochemical	15057270
Intra	CDKN1B	P46527	KPNA5	Homo sapiens	O15131	Anti Tag CoIP	15057270
Intra	CDKN1B	P46527	KPNA5	Homo sapiens	O15131	Pull Down	15057270
Intra	CDKN1B	P46527	COPS5	Homo sapiens	Q92905	IF	12082530
Intra	CDKN1B	P46527	COPS5	Homo sapiens	Q92905	Anti Bait CoIP	12082530
Cross	CDKN1B	P46527	Jak2	Mus musculus	Q62120	Anti Tag CoIP	21423214
Intra	CDKN1B	P46527	SPDYA	Homo sapiens	Q5MJ70	Y2H Array	32296183
Intra	CDKN1B	P46527	SPDYA	Homo sapiens	Q5MJ70	Y2H Prey Pooling	32296183
Intra	CDKN1B	P46527	SPDYA	Homo sapiens	Q5MJ70	Validated Y2H	32296183
Intra	CDKN1B	P46527	THAP1	Homo sapiens	Q9NVV9	Validated Y2H	25910212
Intra	CDKN1B	P46527	THAP1	Homo sapiens	Q9NVV9	Y2H Bait-Prey Pool	25910212
Intra	CDKN1B	P46527	THAP1	Homo sapiens	Q9NVV9	Y2H Array	25910212
Intra	CDKN1B	P46527	CCND2	Homo sapiens	P30279	Validated Y2H	25910212
Intra	CDKN1B	P46527	CCND2	Homo sapiens	P30279	SLC	25910212
Intra	CDKN1B	P46527	CCND2	Homo sapiens	P30279	Y2H Array	25910212
Intra	CDKN1B	P46527	CCND2	Homo sapiens	P30279	Y2H Bait-Prey Pool	25910212
Intra	CDKN1B	P46527	LYN	Homo sapiens	P07948	Anti Bait CoIP	17254966
Intra	CDKN1B	P46527	LYN	Homo sapiens	P07948	Protein Kinase Assay	17254966
Intra	CDKN1B	P46527	CHUK	Homo sapiens	O15111	Protein Kinase Assay	23602409
Cross	CDKN1B	P46527	Abl1	Mus musculus	P00520	Protein Kinase Assay	17254966
Intra	CDKN1B	P46527	RPS6KA1	Homo sapiens	Q15418	Anti Bait CoIP	19470470
Intra	CDKN1B	P46527	RPS6KA1	Homo sapiens	Q15418	Protein Kinase Assay	19470470

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CDKN1B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70037	CDKN1B Protein, Human (His)	P46527 (M1-T198)	≥ 95%, as determined by reducing SDS-PAGE.

CDKN1B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80256	p27 KIP 1 Antibody (YA253)	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse, Rat
HY-P81749	Phospho-p27 KIP 1 (Ser10) Antibody (YA1494)	WB, IHC-P, IP	Human, Mouse, Rat
HY-P81749A	Phospho-p27 Kip 1 (Ser10) Antibody (YA1494) (PBS only)	WB, IHC-P, IP	Human, Mouse, Rat
HY-P85310	p27 KIP 1 Antibody (YA5002)	IHC-P; IHC-F; IF-Tissue	Human
HY-P85310A	p27 KIP 1 Antibody (YA5002)(PBS only)	IHC-P; IHC-F; IF-Tissue	Human
HY-P85705	p27 KIP 1 Antibody (YA5397)	IHC-P, WB	Human, Mouse, Rat
HY-P85970	p27 KIP 1 Antibody (YA5662)	IHC-P, WB, ICC/IF, ELISA	Human
HY-P86556	p27 KIP 1 Antibody (YA6248)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Multiple Endocrine Neoplasia, Type Iv	Multiple Endocrine Neoplasia Type 4 MEN4 Multiple Endocrine Neoplasia 4 Neoplasia, Endocrine, Multiple, Type Iv
Primary Hyperparathyroidism	Familial Primary Hyperparathyroidism Hyperparathyroidism, Primary Hyperparathyroidism Primary Hypocalciuric Hypercalcemia, Familial, Type 1 Familial Benign Hypercalcemia Familial Hyperparathyroidism Parathyroid Enlargement
Bap1 Tumor Predisposition Syndrome	Bap1-Related Tumor Predisposition Syndrome Common Syndrome Bap1 Cancer Syndrome Bap1-Tpds Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, And Other Internal Neoplasms Tumor Predisposition Syndrome Tumor Susceptibility Linked To Germline Bap1 Mutations Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, Other Internal Neoplasms Tumor Predisposition
Inherited Cancer-Predisposing Syndrome	Hereditary Cancer-Predisposing Syndrome
Neuroendocrine Tumor	Neuroendocrine Neoplasm Neuroendocrine Tumors Carcinoma, Neuroendocrine
Multiple Endocrine Neoplasia, Type I	Multiple Endocrine Neoplasia Type 1 MEN1 Wermer Syndrome Multiple Endocrine Neoplasia 1 Multiple Endocrine Neoplasia, Type 1 Men I Endocrine Adenomatosis, Multiple Mea I Men Type I Wermer'S Syndrome Men1 Syndrome Multiple Endocrine Adenomatosis Endocrine Adenomatosis Multiple Men 1 Familial Multiple Endocrine Neoplasia Type I Neoplasia, Endocrine, Multiple, Type 1 Multiple Endocrine Neoplasia
Multiple Endocrine Neoplasia	Men Multiple Endocrine Adenomatosis Multiple Endocrine Neoplasia Syndrome Adenomatosis, Familial Endocrine Endocrine Neoplasia, Multiple Familial Endocrine Adenomatosis Mea Multiple Endocrine Neoplasms Multiple Endocrine Neoplasia Type 1
Inverted Papilloma	Inverted Papilloma, Squamous Cell Papilloma Inverted Papilloma, Inverted Inverted Squamous Cell Papilloma
Tonsil Cancer	Tonsillar Neoplasms Malignant Neoplasm Of Faucial Tonsil Malignant Neoplasm Of Palatine Tonsil Malignant Neoplasm Of Tonsil, Faucial Malignant Tonsillar Tumor Malignant Tumor Of Tonsil Tonsillar Carcinoma Malignant Neoplasm Tonsil
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Hyperparathyroidism	Hyperparathyroidism And Other Disorders Of Parathyroid Gland Parathyroid Hyperfunction Hpth - [Hyperparathyroidism] Parathyroid Gland Hyperfunction Parathyroid Glandular Hyperfunction
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Hypervitaminosis A	Hypervitaminosis A, Susceptibility To Hyperalimentation Of Vitamin A
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Squamous Cell Skin Cancer Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Small Intestine Neuroendocrine Neoplasm	Small Intestine Neuroendocrine Tumor Neuroendocrine Tumor Of The Small Intestine Net Of The Small Intestine Neuroendocrine Neoplasm Of The Small Intestine Neuroendocrine Tumor Of Small Bowel Small Intestinal Neuroendocrine Neoplasm
Mucoepidermoid Carcinoma	Mec Salivary Gland Mucoepidermoid Carcinoma C3772 Carcinoma Mucoepidermoid Carcinoma, Mucoepidermoid
Ameloblastoma	Adenoameloblastoma
Anaplastic Large Cell Lymphoma	Alcl Cd30 Positive Anaplastic Large Cell Lymphoma Ki-1 Positive Anaplastic Large Cell Lymphoma Primary Systemic Alcl Sacl Ki-1+ Anaplastic Large Cell Lymphoma
Papilloma	Papillomatosis
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Prolymphocytic Leukemia	Pll Prolymphocytic Leukaemia Leukemia Prolymphocytic Leukemia, Prolymphocytic
Pancreatic Adenocarcinoma	Adenocarcinoma Of The Pancreas Adenocarcinoma Of Pancreas Pancreas Adenocarcinoma Malignant Exocrine Neoplasm Primary Pancreatic Adenocarcinoma Adenocarcinoma Of Islet Cell Of Pancreas Islet Cell Adenocarcinoma Of Unspecified Site Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Pituitary Adenoma	Adenoma Of The Pituitary Gland Pituitary Adenomas Adenoma, Pituitary Pituitary Gland Adenoma Pituitary Neoplasms
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Lymphoblastic Lymphoma	Lymphoma, Lymphoblastic Lymphoma Lymphoblastic Precursor Cell Lymphoblastic Lymphoma Precursor Cell Lymphoblastic Leukemia Lymphoma
Pituitary Cancer	Pituitary Carcinoma Malignant Pituitary Neoplasm Malignant Tumor Of Pituitary Gland Neoplasm Of Pituitary Gland Pituitary Gland Cancer Pituitary Gland Neoplasm Pituitary Neoplasm Carcinoma Of The Pituitary Gland Neoplasm Of The Pituitary Gland Pituitary Neoplasms Malignant Neoplasm Of Pituitary Gland
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Papillary Carcinoma	Carcinoma, Papillary Carcinoma Papillary
Oral Squamous Cell Carcinoma	Mouth Squamous Cell Carcinoma Squamous Cell Carcinoma Of Mouth
Adenoma	Acinar Cell Adenoma Adenomas Acinic Cell Adenoma
Parathyroid Adenoma	Adenoma Of Parathyroid Adenoma Of The Parathyroid Gland Parathyroid Gland Adenoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Hematologic Cancer	Hematologic Neoplasm Hematologic Neoplasms Hematologic Malignancies Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Kaposi Sarcoma	Kaposi'S Sarcoma Kaposi Sarcoma, Susceptibility To Kaposi'S Sarcoma Of Lung Kaposi'S Sarcoma Of Palate Kaposi'S Sarcoma Of Soft Tissue Kaposi'S Sarcoma-Associated Herpesvirus Multiple Idiopathic Pigmented Hemangiosarcoma Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To African Lymphadenopathic Kaposi'S Sarcoma Anal Kaposi'S Sarcoma Cardiac Kaposi'S Sarcoma Central Nervous System Kaposi'S Sarcoma Conjunctival Kaposi'S Sarcoma Corneal Kaposi'S Sarcoma Cutaneous Kaposi'S Sarcoma Esophageal Kaposi'S Sarcoma Gallbladder Kaposi'S Sarcoma Gastric Kaposi'S Sarcoma Intestinal Kaposi'S Sarcoma Kaposi'S Sarcoma Of Anus Kaposi'S Sarcoma Of Central Nervous System Kaposi'S Sarcoma Of Conjunctiva Kaposi'S Sarcoma Of Cornea Kaposi'S Sarcoma Of Esophagus Kaposi'S Sarcoma Of Gastrointestinal Sites Kaposi'S Sarcoma Of Heart Kaposi'S Sarcoma Of Lymph Nodes Kaposi'S Sarcoma Of Penis Kaposi'S Sarcoma Of Skin Kaposi'S Sarcoma Of Soft Tissues Kaposi'S Sarcoma Of The Cns Kaposi'S Sarcoma Of The Gallbladder Kaposi'S Sarcoma Of The Prostate Kaposi'S Sarcoma, Lung Kaposi'S Sarcoma, Skin Lymph Node Kaposi'S Sarcoma Lymphadenopathic Kaposi'S Sarcoma Palate Kaposi'S Sarcoma Penis Kaposi'S Sarcoma Prostate Kaposi'S Sarcoma Pulmonary Kaposi'S Sarcoma Soft Tissue Kaposi'S Sarcoma Hhv8 Human Herpesvirus 8 Kshv Kaposi Sarcoma Herpesvirus Mediterranean Kaposi Sarcoma Non Aids Related Kaposi Sarcoma Sarcoma, Kaposi Sarcoma, Kaposi, Susceptibility To Non-Aids-Related Kaposi Sarcoma Angiolymphoid Hyperplasia Angiofollicular Ganglionic Hyperplasia Multi-Centric Castleman'S Disease
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Familial Hypocalciuric Hypercalcemia	Familial Benign Hypercalcemia Fbh Fbhh Fhh Familial Benign Hypocalciuric Hypercalcemia Hypocalciuric Hypercalcemia, Familial, Type 1
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Small Intestine Benign Neoplasm	Neoplasm Of Small Intestine Small Intestinal Neoplasm Neoplasm Of The Small Intestine Small Bowel Cancer Small Intestine Cancer Malignant Neoplasm Of Small Intestine, Unspecified Malignant Tumour Of Small Bowel Malignant Tumour Of Small Intestine Primary Malignant Neoplasm Of Meckel Diverticulum
Cervical Adenocarcinoma	Adenocarcinoma Cervix Uteri Adenocarcinoma Of Cervix Adenocarcinoma Of The Uterine Cervix Adenocarcinoma Of The Cervix Uteri
Cholangiocarcinoma	Cholangiocarcinoma, Susceptibility To Extrahepatic Cholangiocarcinoma Intrahepatic Cholangiocarcinoma Chlc Chlc, Susceptibility To Cc Cholangiocarcinoma Of Biliary Tract Cholangiocellular Carcinoma Distal Cholangiocarcinoma Perihilar Cholangiocarcinoma Bile Duct Cancer Cca Adult Primary Cholangiocellular Carcinoma Bile Duct Carcinoma
Breast Ductal Carcinoma	Ductal Breast Carcinoma Duct Carcinoma Carcinoma, Ductal Mammary Ductal Carcinoma Ductal Carcinoma
Reticulosarcoma	Histiocytic Lymphoma Large-Cell Lymphomas Lymphoma, Large-Cell Lymphoma Large Cell Diffuse Large B-Cell Lymphoma Histiocytic Sarcoma
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Carney Complex Variant	Carney Complex Carney Syndrome Carney Complex, Type 1 Lamb Syndrome Name Syndrome Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome Carney Complex - Trismus - Pseudocamptodactyly Syndrome Carney Complex, Type 2 Car Cnc1 Carney Myxoma-Endocrine Complex Myxoma - Spotty Pigmentation - Endocrine Overactivity Myxoma, Spotty Pigmentation, And Endocrine Overactivity Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome Carney Complex-Trismus-Pseudocamptodactyly Syndrome CACOV
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Multiple Endocrine Neoplasia, Type Iia	Multiple Endocrine Neoplasia Type 2a Sipple Syndrome Multiple Endocrine Neoplasia Type 2 MEN2A Men2 Ptc Syndrome Multiple Endocrine Neoplasia, Type 2 Multiple Endocrine Neoplasia Iia Men 2a Pheochromocytoma And Amyloid Producing Medullary Thyroid Carcinoma Multiple Endocrine Neoplasia, Type 2a Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma Multiple Endocrine Neoplasia Ii Men2 Syndrome Men-2a Syndrome Multiple Neoplasia 2a Multiple Neoplasia Type 2
Maxillary Sinus Adenocarcinoma	Adenocarcinoma Of Maxillary Sinus Adenocarcinoma Of The Maxillary Sinus
Cervical Squamous Cell Carcinoma	Squamous Cell Carcinoma Of The Cervix Uteri Squamous Cell Carcinoma Of Cervix
Hypocalciuric Hypercalcemia, Familial, Type I	HHC1 Familial Hypocalciuric Hypercalcemia 1 Fhh1 Familial Benign Hypercalcemia 1 Fbh1 Hypocalciuric Hypercalcemia, Type I Fhh Type 1 Hhc Fhh Hypercalcemia, Familial Benign Hypocalciuric Hypercalcemia Type I Familial Hypocalciuric Hypercalcemia Type 1 Hypocalciuric Hypercalcemia, Familial, Type 1 Familial Hypocalciuric Hypercalcemia Type I Familial Benign Hypercalcemia Type 1 Hypercalcemia, Familial Benign Type 1 Hypocalciuric Hypercalcemia, Familial 1 Familial Benign Hypocalciuric Hypercalcemia 1 Fbhh1
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Cervical Cancer	Cervical Cancer, Somatic Neoplasm Of Uterine Cervix Cervix Cancer Uterine Cervical Neoplasm Cervical Neoplasm Cervix Uteri Cancer Tumor Of The Cervix Uteri CERCA Uterine Cervical Cancer Neoplasms Cervical Uterine Cervical Neoplasms Cervical Cancers Cancer, Cervical, Somatic Malignant Tumor Of Cervix Cervix Carcinoma
Multiple Endocrine Neoplasia, Type Iib	Multiple Endocrine Neoplasia Type 2b MEN2B Wagenmann-Froboese Syndrome Multiple Endocrine Neoplasia Iib Mucosal Neuroma Syndrome Multiple Endocrine Neoplasia, Type 3 Multiple Endocrine Neoplasia, Type 2b Men Iib Neuromata, Mucosal, With Endocrine Tumors Multiple Endocrine Neoplasia, Type Iii, Formerly Men3, Formerly Men Type Iib Men 2b Multiple Endocrine Neoplasia Type 3 Multiple Neoplasia 2b Neoplasia, Endocrine, Multiple, Type Iib
Lissencephaly, X-Linked, 2	X-Linked Lissencephaly With Abnormal Genitalia Hydranencephaly With Abnormal Genitalia Xlag Xlisg X-Linked Lissencephaly With Ambiguous Genitalia LISX2 Lissencephaly, X-Linked 2 X-Linked Lissencephaly 2 X-Linked Lissencephaly-Corpus Callosum Agenesis-Genital Anomalies Syndrome Xlag Syndrome Lissencephaly, X-Linked, With Ambiguous Genitalia Xlis2 X-Linked Lissencephaly - Agenesis Of The Corpus Callosum - Genital Anomalies X-Linked Lissencephaly-Agenesis Of The Corpus Callosum-Genital Anomalies Syndrome Xlag Syndrome Lissencephaly X-Linked With Ambiguous Genitalia Lissencephaly, X-Linked, Type 2 Chromosome Xq26.3 Duplication Syndrome
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Gallbladder Cancer	Gallbladder Carcinoma Gallbladder Neoplasm Malignant Neoplasm Of Gallbladder Malignant Tumour Of Gallbladder Gallbladder Ca Localized Malignant Gallbladder Neoplasm Malignant Tumor Of The Gallbladder Tumor Of The Gallbladder Cancer Of The Gallbladder Carcinoma Gallbladder Carcinoma Of Gallbladder Gallbladder Neoplasms Malignant Neoplasm Of Gallbladder Localized Cancer Of Gallbladder Primary Malignant Neoplasm Of Gallbladder
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Trichorhinophalangeal Syndrome, Type I	Trichorhinophalangeal Dysplasia Type I TRPS1 Trichorhinophalangeal Syndrome Type I Trps I Trichorhinophalangeal Syndrome Type 1 Type I Trichorhinophalangeal Syndrome Giedion Syndrome Trp Syndrome Tricho-Rhino-Phalangeal Syndrome 1 Trichorhinophalangeal Syndrome, Type Iii
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Functioning Pituitary Adenoma	Secretory Adenoma Of The Pituitary Gland Endocrine Active Pituitary Adenoma Secreting Pituitary Adenoma Pituitary Adenoma, Functioning
Immunodeficiency 49	IMD49 Severe Combined Immunodeficiency, T Cell-Negative, B Cell-Positive, Nk Cell-Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities Scid, T Cell-Negative, B Cell-Positive, Nk Cell-Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities Immunodeficiency 49, Severe Combined Scid, T-Cell Negative, B-Cell Positive, Nk Cell Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities Severe Combined Immunodeficiency, T-Cell Negative, B-Cell Positive, Nk Cell Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities Scid, T-Cell-Negative, B-Cell-Positive, Nk-Cell-Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities
Retinal Cancer	Malignant Neoplasm Of Retina Retinal Neoplasms Malignant Retinal Neoplasm Malignant Tumor Of Retina Neoplasm Of Retina Retinal Tumor Retinal Neoplasm Cancer Of The Retina Malignant Retinal Tumour Malignant Tumour Of Retina Primary Malignant Neoplasm Of Retina
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Pituitary Gland Disease	Pituitary Diseases Pituitary Dysfunction Pituitary Disease Pituitary Deficiency Pituitary Disorders
Rhabdomyosarcoma
Ocular Cancer	Eye Neoplasm Eye Carcinoma Eye Cancer Eye Neoplasms Malignant Eye Neoplasm Neoplasm Of Eye Neoplasm Of Eye Proper Ocular Tumor Carcinoma Of Eye Ocular Carcinoma Malignant Tumor Of Eye
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Vallecula Cancer	Malignant Tumor Of Vallecula
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Melanoma, Cutaneous Malignant 1	Familial Melanoma Melanoma, Cutaneous Malignant, Susceptibility To, 1 Melanoma, Malignant CMM1 Melanoma, Cutaneous Malignant Cmm Familial Atypical Mole-Malignant Melanoma Syndrome Fammm Melanoma, Familial Mlm Dysplastic Nevus Syndrome, Hereditary Dns B-K Mole Syndrome Melanoma, Cutaneous Malignant, 1 Malignant Melanoma, Cutaneous Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1 Dysplastic Nevus Syndrome Cutaneous Melanoma Familial Atypical Mole Melanoma Syndrome Hereditary Melanoma
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-161989	DZ-837	Degrader	96.04%	Unkown
HY-RS19053	Cdkn1b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02412	CDKN1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25543	Cdkn1b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CDKN1B	VGNC	VGNC:27143
Canis familiaris	CDKN1B	VGNC	VGNC:39069
Mus musculus	CDKN1B	MGD	MGI:104565
Rattus norvegicus	CDKN1B	RGD	RGD:69062
Macaca mulatta	CDKN1B	VGNC	VGNC:108332
Others	CDKN1B	NCBI