Grm6 - glutamate metabotropic receptor 6 Gene

Also Known as mGluR6

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24419

About Grm6

Primary_assembly 10: 35,167,985-35,182,717 forward strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 250 orthologues, 7 paralogues and is associated with 5 phenotypes. Biased expression in Brain (RPKM 2.1), Testes (RPKM .8) and 6 other tissues.

Summary

Enables Adenylate Cyclase inhibiting G protein-coupled glutamate receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway and chemical synaptic transmission. Predicted to be located in Golgi membrane; endoplasmic reticulum membrane; and new growing cell tip. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1B. Orthologous to human GRM6 (glutamate metabotropic receptor 6). [provided by Alliance of Genome Resources, Apr 2022]

Grm6 Products (1)

mRNA Protein Name
NM_022920.2 NP_075209.1 metabotropic glutamate receptor 6 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity IDA
IDA: Inferred from direct assay
8389366 RGD
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway IDA
IDA: Inferred from direct assay
8389366 RGD
involved in chemical synaptic transmission IEP
IEP: Inferred from expression pattern
8389366 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Grm6 Protein Structure

PBP1_mGluR_groupIII

PBP1_mGluR_groupIII: cd06376 (38 - 499)

NCD3G

NCD3G: pfam07562 (507 - 557)

7tm_GPCRs

7tm_GPCRs: cl28897 (577 - 849)

7tm_GPCRs

7tm_GPCRs: cd14964 (578 - 602)

7tm_GPCRs

7tm_GPCRs: cd14964 (614 - 635)

7tm_GPCRs

7tm_GPCRs: cd14964 (644 - 666)

7tm_GPCRs

7tm_GPCRs: cd14964 (692 - 708)

7tm_GPCRs

7tm_GPCRs: cd14964 (740 - 763)

7tm_GPCRs

7tm_GPCRs: cd14964 (775 - 797)

7tm_GPCRs

7tm_GPCRs: cd14964 (807 - 832)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 871 a.a.
Protein Preferred Names Protein Names

metabotropic glutamate receptor 6

  • glutamate receptor, metabotropic 6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05834 GRM6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05835 Grm6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05836 Grm6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grm6 NCBI NCBI:2916